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Patent Theme

Immune Checkpoint Modulation

Therapeutic interventions that target immune checkpoint pathways to either enhance or suppress immune responses, often used in cancer immunotherapy or autoimmune diseases.

8,349 US filings from 3,054 companies since 2023 · 2023: 2,130 · 2024: 2,738 · 2025: 2,495 · 2026 YTD: 986

Therapeutic Activity (Pharma)

Top companies

Ranked by filings in this theme since 2023. 2026 is partial.

#CompanySince 20232023202420252026 YTDYoY
1Bristol-Myers Squibb Company18444615227-14.8%
2The Regents of the University of California127323838190.0%
3Genentech, Inc.11723413716-9.8%
4Dana-Farber Cancer Institute, Inc.952628338+17.9%
5Regeneron Pharmaceuticals, Inc.9519303214+6.7%
6Hoffmann-La Roche Inc.9120302417-20.0%
7Board of Regents, The University of Texas System9026232516+8.7%
8Novartis AG822528209-28.6%
9The Board of Trustees of the Leland Stanford Junior University822925217-16.0%
10KING FAISAL UNIVERSITY7536210·-83.9%
11Merck Sharp & Dohme LLC7112232115-8.7%
12H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.691326219-19.2%
13Memorial Sloan Kettering Cancer Center682018237+27.8%
14Incyte Corporation561415243+60.0%
15The Johns Hopkins University552215144-6.7%
16Gilead Sciences, Inc.461017163-5.9%
17JANSSEN BIOTECH, INC.45818172-5.6%
18Cue Biopharma, Inc.44921104-52.4%
19THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA441016117-31.2%
20MASSACHUSETTS INSTITUTE OF TECHNOLOGY41618143-22.2%
21Pfizer Inc.391212105-16.7%
22Emory University381011125+9.1%
23The General Hospital Corporation381111124+9.1%
24AMGEN INC.37851410+180.0%
25CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE34310165+60.0%