Patent Theme
Molecular Biomarkers for Disease
Identification and measurement of specific nucleic acid sequences (DNA, RNA), their expression levels, or epigenetic modifications (e.g., methylation) as indicators for disease presence, progression, risk, or treatment response.
7,286 US filings from 2,857 companies since 2023 · 2023: 1,810 · 2024: 2,372 · 2025: 2,177 · 2026 YTD: 927
Genetic & Microbiological Assays
Top companies
Ranked by filings in this theme since 2023. 2026 is partial.
| # | Company | Since 2023 | 2023 | 2024 | 2025 | 2026 YTD | YoY |
|---|
| 1 | Guardant Health, Inc. | 151 | 19 | 51 | 53 | 28 | +3.9% |
| 2 | The Regents of the University of California | 121 | 24 | 35 | 44 | 18 | +25.7% |
| 3 | The Johns Hopkins University | 94 | 23 | 27 | 31 | 13 | +14.8% |
| 4 | Illumina, Inc. | 89 | 11 | 26 | 40 | 12 | +53.8% |
| 5 | 10x Genomics, Inc. | 86 | 29 | 30 | 19 | 8 | -36.7% |
| 6 | Foundation Medicine, Inc. | 80 | 6 | 10 | 40 | 24 | +300.0% |
| 7 | NATIONAL CANCER CENTER | 74 | 15 | 32 | 17 | 10 | -46.9% |
| 8 | The Board of Trustees of the Leland Stanford Junior University | 72 | 21 | 20 | 22 | 9 | +10.0% |
| 9 | The General Hospital Corporation | 68 | 17 | 24 | 19 | 8 | -20.8% |
| 10 | Board of Regents, The University of Texas System | 63 | 12 | 25 | 20 | 6 | -20.0% |
| 11 | Toray Industries, Inc. | 63 | 14 | 29 | 14 | 6 | -51.7% |
| 12 | GRAIL, LLC | 59 | 18 | 36 | 5 | · | -86.1% |
| 13 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 55 | 17 | 22 | 9 | 7 | -59.1% |
| 14 | The Broad Institute, Inc. | 55 | 14 | 25 | 9 | 7 | -64.0% |
| 15 | Dana-Farber Cancer Institute, Inc. | 51 | 12 | 17 | 13 | 9 | -23.5% |
| 16 | The Chinese University of Hong Kong | 46 | 10 | 16 | 15 | 5 | -6.2% |
| 17 | LIFE TECHNOLOGIES CORPORATION | 45 | 15 | 14 | 13 | 3 | -7.1% |
| 18 | Roche Sequencing Solutions, Inc. | 44 | 21 | 13 | 8 | 2 | -38.5% |
| 19 | Exact Sciences Corporation | 42 | 12 | 11 | 14 | 5 | +27.3% |
| 20 | GRAIL, Inc. | 41 | 3 | 5 | 22 | 11 | +340.0% |
| 21 | Quest Diagnostics Investments LLC | 41 | 11 | 14 | 11 | 5 | -21.4% |
| 22 | Genentech, Inc. | 40 | 5 | 14 | 14 | 7 | 0.0% |
| 23 | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY | 39 | 10 | 13 | 8 | 8 | -38.5% |
| 24 | KONINKLIJKE PHILIPS N.V. | 39 | 18 | 10 | 8 | 3 | -20.0% |
| 25 | Becton, Dickinson and Company | 37 | 11 | 11 | 12 | 3 | +9.1% |