ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA

A method for evaluating a capacity of a serum to neutralize a virus is disclosed. The method includes preparing a solution comprising at least one cell, a serum and a virus, placing the solution in contact with an organic electrochemical transistor comprising a source, a drain and a gate electrode, wherein the source and drain electrodes are electrically connected by means of a conductive channel, applying a potential difference between the drain and source electrode, applying a plurality of pulses of a potential difference between the gate and source electrode and measuring a respective plurality of values of pulses of current flowing through the channel; calculating a value of an estimation of a response time of the transistor, and comparing the value of the estimated response time with respect to a threshold value and detecting whether the serum has a neutralising capacity against the at least one virus.

An apparatus for sampling and detecting a pathogen in air comprising a first air sampling module, a second module for the isolation of viral RNA and a third module for amplification and detection of the viral RNA; thanks to the integration between the modules the apparatus is compact and portable and can be used for in situ sampling of air in closed environments such as ambulances or hospital rooms, air in the external environment and air exhaled by patients.

The present invention relates to a phage or a composition that comprises it, wherein said phage expresses at least one specific recognition element and is furthermore conjugated with at least 300 molecules of a sonosensitiser. The invention further relates to the use of said phage in a sonodynamic therapy.

The present invention relates to a method for forming functional materials, and particularly cross-linked active matrices, for regulating, limiting and blocking oxygen in in vitro cell culturing and packaging for food and beverages, onto a target substrate, as well as to functional substrates obtainable from said methods and kits to be used in said methods.

Metal based nanoparticles coated with a polymer functionalized with thiol groups and —NH groups are provided. The polymer can be thiolated chitosan, thiolated and aminated alginic acid, thiolated and aminated hyaluronic acid, or a protein such as albumin or gelatin, or a synthetic thiolated and aminated polymer such as α-thio-ω-amino polyethylene glycols. The groups are linked to a ligand of the integrin family receptors via a heterobifunctional crosslinker bearing functional groups able to bind to amino groups such as N-hydroxysuccinimidyl ester group (NHS ester), an isocyanate group (—NCO), an isothiocyanate group (—NCS), a Sulfo-N-hydroxysuccinimidyl ester group (sulfo-NHS ester), or a carboxylic acid group which is connected by activation with carbodiimide coupling agents; and/or a functional group able to bind thiol groups.

Apparatuses, systems, and methods for implementing temporal lockstep for error detection utilizing a single processor are provided. For example, a processor includes a controller, wherein the controller includes a finite state machine comprising a plurality of states. The processor, based at least on the plurality of states of the finite state machine, is configured to fetch a first instruction, generate a first dummy instruction based on the first instruction and a first real instruction based on the first instruction, execute the first dummy instruction to generate a first dummy result; store the first dummy result in a first dummy buffer, execute the first real instruction to generate a first real result, and compare the first dummy result stored in the first dummy buffer with the first real result to identify an error.

The present invention relates to a synthetic peptide comprising the following elements from the N-terminus to the C-terminus: a) a first cell-penetrating peptide or functional fragments or derivatives, or biologically active variants thereof and b) a second peptide with agonist activity of OR1 and OR2 receptors or functional fragments or derivatives, or biologically active variants thereof.

A NAB815 compound having the following formula (I), wherein: L is OA, R1 is -Dab, R2 is -Thr, R3 is -DThr, R4 is -Dab, R5 is -Dab, R6 is -DPhe, R7 is -Leu, R8 is -Abu, R9 is -Dab, R10 is -Thr, or a pharmaceutically acceptable salt thereof is provided for a use in the treatment and/or the prevention of the hemolytic-uremic syndrome.

Apparatuses, systems, and methods for implementing temporal lockstep for error detection utilizing a single processor core are provided. For example, a processor core includes a pipeline with an instruction fetch circuit and an instruction decode and execute circuit. The instruction decode and execute circuit comprises a controller including a finite state machine with a plurality of states to control the processor core. A voting circuit is provided to vote on a control signal to control the finite state machine for transitioning from a current state to a next state. The processor core, based at least on the plurality of states of the finite state machine, is configured to: execute the first dummy instruction to generate a first dummy result; store the first dummy result in a first dummy buffer; execute the first real instruction to generate a first real result; compare the results to identify an error.

Apparatuses, systems, and methods for implementing temporal lockstep for error detection utilizing a single processor core are provided. For example, a processor core includes a pipeline with an instruction fetch circuit and an instruction decode and execute circuit. The instruction decode and execute circuit comprises a controller including a finite state machine with a plurality of states to control the processor core. A voting circuit is provided to vote on a control signal to control the finite state machine for transitioning from a current state to a next state. The processor core, based at least on the plurality of states of the finite state machine, is configured to: execute the first dummy instruction to generate a first dummy result; store the first dummy result in a first dummy buffer; execute the first real instruction to generate a first real result; compare the results to identify an error.