CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

The present invention relates to a benzo seven-membered ring bifunctional compound and an application thereof, and in particular to a compound represented by formula (IV) and a pharmaceutically acceptable salt thereof. The compound can be used for preparing a drug for treating diseases related to an estrogen receptor protein degradation targeting chimera.

Provided are an antibody binding to GPRC5D and a use thereof. Specifically provided are an anti-GPRC5D antibody and an antigen-binding fragment thereof, a nucleic acid encoding same, a vector comprising the nucleic acid, a cell comprising the vector, and a pharmaceutical composition comprising same. Further provided is a use thereof in reducing tumors or inhibiting tumor cell growth, treating diseases, etc.

A treatment use of a pyrrolopyrimidine compound, and a solid pharmaceutical composition of a pyrrolopyrimidine compound. In particular, the present invention relates to a pyrrolopyrimidine compound or a pharmaceutical composition thereof for treating myeloproliferative neoplasms, and a method therefor or a use thereof.

The present invention relates to a use of a quinolinone derivative in treatment of immune thrombocytopenia, and in particular to a use of a compound of formula (I) or a pharmaceutically-acceptable salt or pharmaceutical composition thereof in treatment of immune thrombocytopenia.

Provided is a fused tri-cyclic compound as PDE3/PDE4 dual inhibitor, and a use thereof in the preparation of drugs for PDE3/PDE4 associated diseases, particularly in medicinal functions such as chronic obstructive pulmonary disease (COPD). Provided are specifically a compound of formula (I) and a pharmaceutically acceptable salt thereof.

The present invention relates to an antibody binding to c-Met and a use thereof; specifically, provided is a single variable domain, an antibody or an antigen-binding fragment thereof, or a fusion protein that binds to c-Met, as well as nucleic acids that encode said products, vectors comprising the nucleic acids, cells comprising the vectors, and pharmaceutical compositions comprising same; also provided are detection, pharmaceutical and therapeutic uses thereof.

Provided is an antibody drug conjugate, specifically comprising a therapeutic antibody moiety, an intermediate linker moiety and a cytotoxic drug moiety which are linked. The therapeutic antibody moiety is an antibody against an HER2 target. The cytotoxic drug moiety is a camptothecin topoisomerase I inhibitor. The cytotoxic drug moiety or the linker-cytotoxic drug moiety is modified by means of deuterium substitution. The antibody drug conjugate can be used for the prevention or treatment of cancers.

Provided is a drug combination of a Toll-like receptor 7 agonist and an anti-PD-L1 antibody. In particular, provided are a drug combination of a compound, which is represented by formula I and which acts as a TLR7 agonist, and an anti-PD-L1 antibody, and a medical use thereof.

A BCMA-binding immunoglobulin single variable structural domain and an antigen-binding molecule including an immunoglobulin single variable structural domain and an antigen-binding molecule, a nucleic acid encoding the above, a vector containing the nucleic acid, a cell containing the vector, and a pharmaceutical composition containing the above, as well as a therapeutic use thereof.

Provided are a combined pharmaceutical composition of an anti-PD-L1 antibody and a c-Met kinase inhibitor, specifically, a combined pharmaceutical composition of an anti-PD-L1 antibody and N-(4-((7-((1-(cyclopentylamino)cyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and the use of the combined pharmaceutical composition in the treatment of cancers, in particular, gastric cancer or liver cancer.