CHILDREN'S NATIONAL MEDICAL CENTER

A method for predicting a severity and appearance of renal obstruction, including receiving, via processing circuitry, a plurality of medical images corresponding to a kidney of a patient, identifying, the kidney in the plurality of medical images, selecting, at least one relevant image from the plurality of medical images based on a relationship to renal function, standardizing the at least one relevant image, determining, via a deep learning model at least one risk score based on the at least one relevant image, and determining, a final ultrasound-based risk score based on the at least one risk score, wherein the final ultrasound-based risk score is a determination of renal obstruction and/or a probability of renal obstruction. Clinical and/or demographic patient information can be used along with the final ultrasound-based risk score to determine a final risk score to predict the severity and appearance of renal obstruction.

The present invention provides a method for preparing an immune cell, such as a tumor-associated antigen-specific T cell (TAA-T cell), which is engineered with an IL-8 receptor. The present application also provides an immune cell, such as a T cell which is tumor-associated antigen-specific and is engineered with an IL-8 receptor. Immune cells (such as T cells) are genetically engineered to bind to IL-8 in the tumor environment that can serve as a potential strategy to improve immunotherapy for pediatric solid tumors.

The circulation assist devices disclosed herein can be used, for example, in methods of decreasing venous pressure in the Fontan circulation. The devices can include an inlet, an outlet, a stator, a rotor, and an impeller driven by rotation of the rotor. In some embodiments, the impeller blade (or blades) can at least partially define a central lumen extending through the device. The device can be coupled to the inferior vena cava and the pulmonary artery. Rotating the impeller blade(s) increases blood velocity through the lumen and causes the outlet pressure to be higher than the inlet pressure. The impeller can be configured such that, when it is stationary, the forward static pressure drop between the inlet and the outlet is minimized. That is, the forward static pressure drop of the device approximates the pressure drop between the inferior vena cava and central pulmonary artery of the unassisted Fontan circulation.

Disclosed herein are compositions that inhibit adipogenesis of a fibro/adipogenic precursor (FAP) cell and methods relating to treating, preventing, reducing, and/or inhibiting a muscular degenerative condition a muscular degenerative condition comprising administering said inhibitors.

Provided herein are activated adoptive T-cell compositions targeting plasma cell dyscrasias such as multiple myeloma and methods of treating plasma cell dyscrasias such as multiple myeloma using such compositions. The T-cell compositions of the present disclosure are activated against a select group of antigens associated with multiple myeloma (MMAAs) and, in certain embodiments, in combination with more widely expressed tumor associated antigens (TAAs). In particular, the T-cell compositions of the present disclosure are directed to the MMAAs selected from B-cell maturation antigen (BCMA), X box Protein 1 (XBP1), CS1, and Syndecan-1 (CD138), or a combination thereof. In certain embodiments, the T-cell composition includes T-cells activated to a TAA selected from preferentially expressed antigen of melanoma (PRAME), Survivin, Wilms' Tumor 1 protein (WT1), and melanoma antigen 3 (MAGE-A3), or a combination thereof.

A method for detecting rheumatic heart disease (RHD) based on at least an echocardiogram, the method including receiving echocardiogram data, extracting first frames corresponding to at least one echocardiogram view from the echocardiogram data, extracting second frames corresponding to ventricular systole from the first frames corresponding to the at least one echocardiogram view, and determining, via at least one machine learning model, an RHD risk score based on the second frames corresponding to ventricular systole.

The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of amino acids with the use of a reaction surface comprising one or a plurality of metabolic enzymes or functional fragments thereof, but wherein the reaction surface does not comprise an electrode or electrically conductive support. In some embodiments, the biosensor comprises use of a thermophilic bacterial metabolic enzyme immobilized or attached to the reaction surface.

The present disclosure relates to non-invasive nerve identification using snapshot polarimetry. The present disclosure further relates to a system for nerve identification, the system comprising a camera including a sensor, and a filter having a linear polarizer array, an illumination system configured to illuminate a target area with polarized light illumination, the polarized light illumination having at least one predetermined polarization angle, the illumination system including one more light sources, and one or more polarizer filters, and a processor configured to process imaging data obtained from the camera, and output a birefringence map of the target area including indicia of a nerve structure.

A device for detecting tracheostomy tube placement, including a housing having an inner wall forming a cylindrical channel through the housing, the cylindrical channel having a first opening and a second opening, a carbon dioxide sensor embedded in a cutout in the inner wall of the housing, a moisture filter removably affixed to the inner wall, and processing circuitry embedded in the housing and configured to determine a level of carbon dioxide in airflow through the cylindrical channel based on data from the carbon dioxide sensor, generate a waveform representing carbon dioxide levels in the airflow through the cylindrical channel, and determine a placement state of a tracheostomy tube that is removably coupled to the first opening of the cylindrical channel based on analysis of the waveform representing the carbon dioxide levels in the airflow, analysis of the waveform considering a physiological factor of the patient having the tracheostomy tube.

The present disclosure is related to a device for gripping catheters that are used in interventional cardiac procedures without causing internal catheter damage. The present disclosure will allow the operator to maintain improved stability and maneuverability compared with current approaches, including, primarily, digital manipulation, which can lead to fatigue, instability and inappropriate catheter movement. Specifically in the pediatric population where small movements can lead to severe and permanent complications, the present disclosure has the potential to increase the safety profile of already high-risk interventional catheterization and electrophysiology procedures.