CLEMSON UNIVERSITY RESEARCH FOUNDATION

A method for fabricating a protonic ceramic energy device includes: coating an electrolyte layer on an anode layer; and densifying the electrolyte layer by a rapid laser reactive sintering (RLRS) process on the electrolyte layer and/or the anode layer to form a half-cell comprising a dense electrolyte and a porous anode.

Bio-based polymer precursors and non-isocyanate polyurethanes (NIPU) and non-isocyanate polyurethane foams (NIPUF) that can be formed from the precursors, as well as methods for the synthesis of the precursors and the polyurethane products are described. The bio-based polymer precursors are formed through functionalization of a bio-based polyol, e.g., lignin, with cyclic carbonates. The bio-based polyol starting materials need not be pre-processed and can include Kraft lignin. NIPU/NIPUF can be synthesized through a ring opening curing reaction of cyclic carbonates of the bio-based polyol precursor with diamines. The carbonates and diamines can include non-toxic bio-based carbonates.

A medical training simulator system is disclosed for procedural skill development and objective feedback. The system includes a simulator base with a common physical interface for receiving modular anatomy units, each unit containing an embedded memory module storing calibration and geometry data. A sensor system features an array of light emitters and an instrumented medical needle with a light detection system to track needle position and detect events such as vessel entry. A controller automatically reads unit-specific data and configures signal processing to provide real-time feedback and infiltration alerts. The platform supports interchangeable anatomy modules simulating structures such as veins, lungs, and spines, enabling training for cannulation, biopsy, and epidural procedures. The system is designed for use in medical education and procedural assessment, offering modularity, accurate event detection, and user feedback to improve clinical skills.

Disclosed herein are novel and advanced technique for the modification of complex coacervates to induce structural changes releasing ribonucleic acid (RNA)-based molecules in response to oxidative stress. This approach leverages the reactivity of reactive oxygen species (ROS) generated during oxidative stress to trigger structural changes in the modified cationic coacervate component that induces phase miscibility and subsequently releases RNA molecules from the coacervate matrix.

To achieve high-power single transverse mode laser, we here propose a supersymmetry (SUSY)-based triple-ridge waveguide semiconductor laser structure, which is composed of an electrically pumped main broad-ridge waveguide located in the middle and a pair of lossy auxiliary partner waveguides. The auxiliary partner waveguides are designed to provide dissipative modes that can phase match and couple with the higher-order modes in the main waveguide. By appropriately manipulating the gain-loss discrimination of the modes in the laser cavity, one can effectively suppress all the undesired higher-order transverse modes while keeping the fundamental one almost unaffected, thereby ensuring stable single-mode operation with a larger emitting aperture and accordingly a higher output power than a conventional single-transverse-mode ridge waveguide diode laser.

In general, the present disclosure is directed to a soyhull-based activated carbon. The soyhull-based activated carbon comprises a Brunauer-Emmett-Teller (BET) surface area of from about 750 m 2 /g to about 2900 m 2 /g and a micropore volume of from about 0.50 cm 3 /g to about 1.2 cm 3 /g.

Methods of identifying elevated levels of one or more biomarkers in a subject for detecting or diagnosing autism in subject is provided. The one or more biomarkers have been identified as biomarkers being elevated in autism. The methods include determining the levels of one or more biomarkers in a biological sample from a subject, wherein the one or more biomarkers comprise one or more single nucleotide polymorphisms (SNPs) found Cox10, RAD1, DKK3, STK32C, AARS2, POLR1C, or a combination thereof. The elevated levels of one or more of these biomarkers may be an indicator of autism in the subject.

Disclosed herein is a system for evaluating a user during a physical cannulation simulation. The system includes a physical cannulation simulator and one or more sensors configured to measure data during the physical cannulation simulation by the user using the physical cannulation simulator. The system further includes one or more processors configured to receive the data measured by each of the one or more sensors and calculate metrics using the data. The one or more processors are further configured to apply a model to the metrics to determine a composite simulation success score and compare the composite simulation success score to a threshold score. In response to comparing the composite simulation success score to the threshold score, the one or more processors are configured to output an indication of one or more of an absolute performance or a relative performance for the first user during the physical cannulation simulation.

This invention is directed to a monoclonal antibody or an antigen binding fragment thereof targeting the expression and function of CYP1A1 with cross reactivity across the vertebrate taxa. This invention is also directed to nucleic acid molecules, vectors, host cells and compositions comprising the same, as well as methods for use of the same and for producing the same.

Antibodies and antigen binding fragments thereof that specifically recognize and bind an epitope of elastin that is exposed and accessible in degraded elastic fiber are described. The antibodies and/or antigen binding fragments can be operably linked to a secondary component, including biologically active agents such as therapeutics and/or imaging agents. Optionally, the antibodies and/or antigen binding fragments thereof can be attached to a surface of a carrier, such as a particle, for specific binding and delivery of the carried agents to degraded elastic fiber.