CooperVision International Limited

Microchannels in hydrogels play an essential role in enabling a smart contact lens. A wearable contact lens is disclosed herein that uses microchannels and connected chambers located in poly-2-hydroxyethyl methacrylate (poly(HEMA)) hydrogel that is used in a commercial contact lens with three-dimensional (3D) printed mold. The corresponding capillary flow behaviors in these microchannels were investigated. Different capillary flow regimes were observed in these microchannels, depending on the hydration level of the hydrogel material. In particular, it was found that a peristaltic pressure could reinstate flow in a dehydrated microchannel, indicating the motion of eye-blinking may help tear flow in a microchannel-containing contact lens. Colorimetric pH and electrochemical Na + sensing capabilities were demonstrated in these microchannels. Micro-engineered contact lenses formed using poly(HEMA) hydrogel can be used for various biomedical applications such as eye-care and wearable biosensing.

An ophthalmic lens ( 1 ) and methods ( 1000 ) of manufacturing an ophthalmic lens are described. The lens ( 1 ) includes an optic zone. The optic zone comprises a central region ( 5 ) having a curvature that is centred on an optical axis ( 19 ), the central region ( 5 ) providing a distance corrective radial curvature power. The central region ( 5 ) has a radial sagittal power profile that increases with increasing radial distance from the optical axis ( 19 ). The gradient of the radial sagittal power profile across the central region ( 5 ) increases with increasing radial distance from the optical axis ( 19 ), following a first curve. A first annular region ( 3 ) circumscribes the central region ( 5 ). The first annular region ( 3 ) provides a radial curvature add power.

A contact lens ( 201 ) and methods of manufacturing such a lens are described. The lens ( 201 ) includes an optic zone ( 202 ). The optic zone ( 202 ) comprises a central region ( 205 ), the central region ( 205 ) having a first optical axis ( 219 ), a base radial curvature power, a base radial sagittal power, and a centre of curvature that is on the first optical axis ( 219 ). The optic zone ( 202 ) comprises an annular region ( 203 ), wherein at a point halfway across the width of the annular region ( 203 ) the annular region ( 203 ) has a radial curvature power of X, wherein X is greater than the base radial curvature power. The annular region ( 203 ) has an off-axis centre of curvature that is a first distance from the optical axis ( 219 ) such that, at a point halfway across its width, the annular region ( 203 ) has a sagittal power of Y, wherein Y is greater than the base radial sagittal power, and wherein Y is less than X.

A contact lens ( 2001 ) and methods of manufacturing such a lens ( 2001 ) are described. The contact lens ( 2001 ) comprises an optic zone ( 202 ). The optic zone ( 202 ) comprises a central portion having a centre of curvature that is on an optical axis ( 219 ), and a first annular portion ( 203 ) extending radially outwards from the central portion ( 205 ). The first annular portion ( 203 ) provides a curvature add power. One of an anterior surface and a posterior surface of the first annular portion ( 203 ) has a centre of curvature that is on the optical axis ( 219 ). The other of the anterior surface and the posterior surface of the first annular portion ( 203 ) has a centre of curvature that is separated by a first distance from the optical axis ( 219 ).

A cationic contact lens is described as well as methods of manufacturing the same. The cationic contact lens includes a polymeric lens body that is the reaction product of a polymerizable composition that includes at least one siloxane, at least one nonionic hydrophilic monomer and at least one acyclic tertiary amine monomer. The cationic contact lens can be an unworn sterile silicone hydrogel contact lens. The contact lens is capable of substantially linear release of a releasable anionic agent and the at least one acyclic tertiary amine monomer facilitates uptake and/or sustained release of the releasable anionic agent by the polymeric lens body. The contact lens can be present in a sealed contact lens package. The sealed contact lens package can include at least a) a base member having a cavity; b) a contact lens packaging solution in the cavity; c) a unworn sterile contact lens immersed in the contact lens packaging solution in the cavity with the releasable anionic agent present; and d) a cover that forms a liquid-tight seal with the base member.

The present invention provides a silicone hydrogel contact lens formulation, comprising a polymerizable siloxane component, a hydrophilic N-vinyl amide monomer, triphenylphosphine (TPP) and one or more of anthraquinone blue tinting agent, a benzophenone UV-absorbing agent or a benzotriazole HEVL absorber; a silicone hydrogel contact lens formed from the polymerisation of the silicone hydrogel contact lens formulation; and the use of an anthraquinone blue tinting agent, a benzophenone UV-absorbing agent and/or a benzotriazole HEVL absorber to stabilise a formulation comprising a polymerizable siloxane component, a hydrophilic N-vinyl amide monomer and TPP.

A contact lens ( 101 ), the lens ( 101 ) including an optic zone ( 102 ). The optic zone ( 102 ) comprises a central region ( 105 ), the central region ( 105 ) having a centre of curvature that is on an optical axis ( 119 ). The optic zone ( 102 ) comprises a first annular region ( 103 ). The first annular region ( 103 ) has an off-axis centre of curvature that is a first distance from the optical axis ( 119 ). The first annular region ( 103 ) has a sagittal power profile that increases with increasing radial distance from the optical axis ( 119 ) with a gradient of between 1.0 D/mm and 20.0 D/mm. At a point halfway across the width of the first annular region ( 103 ), the sagittal power matches the average radial sagittal power of the central region ( 105 ).

A contact lens ( 201 ) includes an optic zone ( 202 ) that is centred on an optical axis ( 219 ), and a peripheral zone ( 204 ) surrounds the optic zone ( 202 ). A cross-sectional slice through the optic zone ( 202 ) along a meridian comprises a series of successive arcs ( 203 a - 203 h ) having a radial curvature power profile. The radial curvature power profile increases monotonically with radial distance from the optical axis ( 219 ). Light rays from a distant point source passing through the midpoint of each arc converge toward a point ( 215 ) on the first optical axis ( 203 a - 203 h ). For each arc ( 203 a - 203 h ), light rays from a distant point source pass through that arc ( 203 a - 203 h ) and converge towards a point ( 216 ) that is spaced away from the optical axis by a first distance. Methods of designing and manufacturing such contact lenses ( 201 ) are also described.

A contact lens having an amount of at least one cooling agent and at least one TRPV1 inhibitor releasably adhered is described as well as method of manufacturing the same. The contact lens can be comfortably worn by contact lens wearers and can increase the duration of comfortable lens wearing time and/or reduce lens awareness events and/or reduce contact lens dryness in a symptomatic contact lens wearer and further can reduce or avoid any stinging/burning sensation when the contact lens is first used or a short time thereafter.

A hydrogel contact lens formulation for forming the polymeric body of a hydrogel contact lens comprising: a first high energy visible light (HEVL) absorber comprising a benzotriazole moiety and a second different high energy visible light (HEVL) absorber comprising a benzotriazole moiety, and a hydrogel contact lens obtained from the polymerisation of the formulation.