EMD Millipore Corporation

The present invention provides compact spiral-wound filter elements having cassette-like performance. The invention further provides filtration systems (e.g., TFF systems) and processes (e.g., SPTFF processes) employing compact spiral-wound filter elements having cassette-like performance.

The present disclosure is directed to methods and/or uses of oligonucleotide conjugates for assays and flow cytometry detections and related systems and/or kits. Certain methods are directed to a method for detecting one or more biological targets of a sample in a detection assay, comprising: providing a molecular probe, comprising a binding moiety and an oligonucleotide sequence, to a sample comprising one or more biological targets; binding the one or more biological targets with the binding moiety; providing a detectable component to the sample, wherein the detectable component comprises a signal generating moiety conjugated to an oligonucleotide sequence complementary to the oligonucleotide sequence of the molecular probe; hydridizing the oligonucleotide sequence of the target-bound molecular probe to the detectable component; and detecting a signal generated from the hydridized detectable component. Various other embodiments, applications etc. are disclosed herein.

A multi-layered flexible sparger ( 100 ) that has a bottom film layer ( 102 ), a middle film layer ( 106 ), and a top film layer ( 110 ); a first inner mesh ( 104 ) disposed between the bottom film layer and the middle film layer: a second inner mesh ( 114 ) disposed between the middle film layer and the top film layer; and a port capable of delivering a gas to the multi-layered flexible sparger disposed between the top film layer and the bottom film layer, wherein the middle film layer includes drill holes and the top film layer includes drill holes.

Some embodiments of the present disclosure comprise a flow diverter for use in a biocontainer or bioreactor, comprising a shoulder having a first surface and a second surface opposite the first surface, a conduit extending from the first surface of the shoulder, an inlet at a first end of the conduit, wherein the first end comprises a connector, an outlet formed within the second surface of the shoulder in fluid communication with the inlet at an end opposite the first end of the conduit and a hood adjacent to the outlet, wherein a fluid diverter is capable of directing a fluid down a sidewall of the biocontainer or bioreactor, attenuating a splashing or foaming condition.

A removal tool for sample well combs that is configured to aid in the extraction of a sample well comb from an electrophoresis gel. The removal tool may be either removably coupled to the sample well comb or may be permanently affixed to the sample well comb in order to provide a surface/region that is more easily graspable by a user to aid in the extraction of the sample well comb. The removal tool may include one or more engagement members that may be at least partially disposed within an opening of the sample well comb to couple the removal tool to the sample well comb. The removal tool may also include a mechanism that is configured to impart extraction forces to a surface in proximity to the sample well comb to further aid in the extraction of the sample well comb.

A sample-directing manifold that includes (a) a plurality of sample inlets, one or more of the sample inlets having a sample outlet valve and a waste outlet valve, (b) a sample outlet path, (c) a waste outlet path, (d) a gas inlet valve, (e) a fluid inlet valve, and (f) an outlet path isolation valve.

The disclosure herein relates to a method of reducing background noise during integrity testing of membrane filter to increase sensitivity and more effectively disposition failing membrane filters.

Some embodiments of the present disclosure comprise a flow diverter for use in a biocontainer or bioreactor, comprising a shoulder having a first surface and a second surface opposite the first surface, a conduit extending from the first surface of the shoulder, an inlet at a first end of the conduit, wherein the first end comprises a connector, an outlet formed within the second surface of the shoulder in fluid communication with the inlet at an end opposite the first end of the conduit and a hood adjacent to the outlet, wherein a fluid diverter is capable of directing a fluid down a sidewall of the biocontainer or bioreactor, attenuating a splashing or foaming condition.

A method and a respective system for performing a chemical synthesis via a computer by Defining an organic target molecule of the chemical synthesis to be produced in the chemical production plant; Providing information describing the organic target molecule to a software-based platform being hosted by a computer connected to a network, wherein the platform holds inventories of chemical suppliers and the inventories contain information about synthetic reagents needed for the chemical synthesis; Routing the chemical synthesis via the computer, wherein the computer checks the inventories of the platform for the synthetic reagents to perform the chemical synthesis by comparing the information describing the organic target molecule and the information in the inventories and connects those chemical suppliers to the chemical production plant which provide synthetic reagents according to the compared information; and Producing the desired organic target molecule in the chemical production plant.