Instrumentation Laboratory Company

An example system includes a detector configured to detect a value that is based on a hematocrit of a test sample containing plasma and red blood cells, a fluidic channel configured to hold the test sample, and an acoustic transducer configured to apply acoustic waves to the fluidic channel to separate the plasma from the red blood cells in the fluidic channel. The acoustic waves have at least one of an amplitude, a frequency, or a duration that is based on the value.

An example method includes: analyzing a clot curve for a test sample that is based on an assay performed on the test sample in order to obtain two or more parameters associated with the clot curve; analyzing the two or more parameters to determine at least one of (i) whether a fibrinogen concentration in the test sample is below a threshold, or (ii) whether there is a therapeutic or pharmaceutical anticoagulant present in the test sample; and outputting, to a user interface, information based on the determination.

An example system includes a flow cell containing a fluidic channel configured to receive a sample, where the sample includes plasma and blood cells. and one or more acoustic transducers configured to output acoustic waves to the fluidic channel. The one or more acoustic transducers are configured (i) to output acoustic waves in a first frequency range to separate the plasma from the blood cells in the fluidic channel, and (ii) to output acoustic waves in a second frequency range to lyse the blood cells in the fluidic channel. The first frequency range includes higher frequencies than the second frequency range. A spectrometer is configured (i) to perform detection on a region of the fluidic channel containing the plasma separated from the blood cells, and (ii) to perform detection on a region of the fluidic channel where the blood cells have been lysed.

An example cartridge includes a base having a channel configured to receive fluid, where the fluid includes a test sample to be tested on the cartridge, and a structure including at least part of a fluidic duct. The structure is configured to move relative to the base between a first position and a second position. In the first position, the channel and fluidic duct are aligned to create a fluidic connection between the channel and the fluidic duct and, in the second position, the channel and the fluidic duct are unaligned to block a fluidic connection between the channel and the fluidic duct.

An example system includes a chamber to hold a mixture that includes a whole blood sample from a patient, a light source to illuminate the mixture in the chamber, a detector to detect light from the light source transmitted through the mixture in the chamber, and one or more processing devices to determine, based on the light detected by the detector, a platelet aggregation value of the whole blood sample that is substantially independent of a hematocrit of the whole blood sample.

A system and method for reducing the responsibility of the user significantly by applying an optical system that can identify container like sample tubes with respect to their characteristics, e.g., shapes and inner dimensions, from their visual properties by capturing images from a rack comprising container and processing said images for reliably identifying a container tyle.

An example sensor includes a conductive electrode and an ion-selective membrane over the conductive electrode. The ion-selective membrane includes an ionophore that is selective for ionized magnesium (iMg) and at least two types of anionic lipophilic salts. The at least two types of anionic lipophilic salts may include one or more fluorinated borate salts and one or more chlorinated borate salts.

An example system includes a detector configured to detect a value that is based on a hematocrit of a test sample containing plasma and red blood cells, a fluidic channel configured to hold the test sample, and an acoustic transducer configured to apply acoustic waves to the fluidic channel to separate the plasma from the red blood cells in the fluidic channel. The acoustic waves have at least one of an amplitude, a frequency, or a duration that is based on the value.

An assay system includes an excitation light source to output excitation light having a first wavelength; an optical reference positioned to absorb the excitation light from the excitation light source and to output an optical signal based on the excitation light, where the optical signal has a second wavelength that is different from the first wavelength; a reaction chamber containing a reactant and an inlet to receive a test sample to produce a fluid that is based on the test sample and the reactant, where the reaction chamber is positioned to receive the optical signal from the optical reference; and an optical receiver positioned to detect an amount of the optical signal that passed through the reaction chamber containing the fluid.