Ohio University

The growth of metal-organic frameworks (MOFs) is most frequently accessed by direct assembly of metal cations and multitopic ready-to-connect ligands under solvothermal conditions. However, such nonambient conditions are expected to impose a synthetic challenge to incorporate degradable ligands into MOFs. This explains why imine-based MOFs are scarce, as the imine motif is usually prone to decompose through hydrolysis. This work not only showcases mechanochemistry as an ambient, sustainable, and high-yield strategy for synthesizing a variety of imine-based MOFs, but also achieves the integration of ligand synthesis and MOF growth into a single tandem step. Thus, this work provides straightforward access to imine-based MOFs, a subfamily of historically challenging MOF materials.

Described are proteolysis targeting chimeras (PROTACs) for use in managing and treating infectious disease. Described compositions can be used to inhibit viral replication associated with coronavirus, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Coronavirus disease 2019 (COVID-19). Methods of synthesizing PROTACs are described. Example PROTAC compositions are provided, including dual targeting compounds having a main protease (Mpro) ligand attached to a linker, an E3 ligase ligand attached to the linker, and a papain-like protease (PLpro) inhibitor attached to the linker. PROTAC compounds useful for degrading Mpro activity and/or PLpro activity, and useful for treating coronavirus infections such as COVID-19, are described.

A drainage management apparatus for collecting and storing stormwater for controlled discharge is provided. The drainage management apparatus includes an upper and a lower slab. The upper slab is spaced a distance from the lower slab. The drainage management apparatus also includes at least one vertical assembly. The at least one vertical assembly includes a column located between the upper and the lower slab and spans the distance separating the upper and the lower slab. The vertical assembly also includes a dome located atop the column such that the dome is supported by the column. The dome protrudes from the upper slab and is configured to carry a load. The drainage management apparatus further includes a plurality of side panels. The plurality of side panels surround the upper slab, the lower slab, and the at least one vertical assembly to form a chamber. The chamber is configured to store stormwater.

A composite is formed from a combination of a polymer and pulverized coal and optionally a compatibilizing agent. The coal forms from about 10 to about 80% of the composite. The composite is form by blending the pulverized coal with the polymer to form the composite.

A system for decontaminating a liquid containing dissolved solids including subjecting liquid containing dissolved solids to Joule heating under conditions effective to cause said dissolved solids to precipitate out of solution.

An electrochemical sensor, including a working electrode, a reference electrode, and a counter electrode. The working electrode may include a transition metal, and is contacted with a solution including an alkaline media for oxidation of the transition metal, such that the sensor may be used to provide data to quantify the amount of a pathogen in the solution. In certain embodiments, the transition metal of the working electrode is nickel. In other embodiments, the working electrode includes graphene-layered nickel. And, in certain embodiments, the working electrode may be a rotating disk electrode, wherein the working electrode rotates in a solution including an alkaline media.

A method of, and apparatus and system for, decontaminating a liquid containing dissolved solids including subjecting liquid containing dissolved solids to Joule heating under conditions effective to cause said dissolved solids to precipitate out of solution.

Methods and FSP27 compositions for treating and/or preventing metabolic disease and conditions associated insulin resistance, obesity, inflammation and dyslipidemia are described.

Described and shown are passive resettable stiffness dampers, which are of compact and simplified design, and configured to produce a damping force that varies optimally with vibration-inducing loading.

Systems, methods, and computer program products for determining the position of a first point in space. A three-dimensional point cloud is generated that comprises a plurality of data points each defining a range from the first point in space to another point in space in a region around the first point. A two-dimensional image is captured of an area including at least some of the points to which ranges have been defined. One or more objects each corresponding to a landmark are identified in the two-dimensional image, and one or more of the data points are mapped to each object. A range to each of the one or more landmarks is determined based on the ranges defined by data points mapped to the objects. A position of the first point in space is then obtained based on known positions of the landmarks using trilateration.