PHC HOLDINGS CORPORATION

Methods and compositions for identifying, quantifying, or characterizing specific biological molecules (e.g., nucleic acids, proteins, metabolites, antibodies) or microbial species, often for diagnostic, prognostic, or quality control applications.

Systems and methods for automated monitoring and dynamic adjustment of environmental parameters (e.g., pH, temperature, oxygen, nutrients) and fluid handling within bioreactors to optimize cell/tissue growth or product synthesis.

Methods and apparatuses for creating unique package structures, such as recesses in specific materials, blister packages, or single-dose units, and for controlled dispensing of products from storage into these containers.

Devices or systems designed to precisely measure and deliver specific doses of medication, often incorporating automated mechanisms, dose-limiting features, or hands-free operation.

Techniques and apparatus for cultivating cells in three-dimensional structures, including organoids, tissue models, and scaffolds, often involving microfluidics, specialized matrices, or mechanical stimulation to mimic in vivo conditions.

Specific heat exchanger designs and auxiliary components tailored for integration into refrigeration, air conditioning, or heat pump systems, often involving gas-liquid separation or rotary mechanisms.

Self-contained or modular devices designed to automate and integrate multiple steps of molecular diagnostic assays, from sample preparation to result interpretation, often for point-of-care or high-throughput applications.

Design and control strategies for improving the efficiency, stability, and operational flexibility of refrigerant circuits, including component integration, flow management, phase separation, and pressure regulation.

Innovations in the mechanical design, aesthetic features, and integrated functionalities of refrigerator doors, including hinges, handles, internal wiring, and lighting.

Systems that integrate digital technology, sensors, or connectivity to monitor, track, or automate aspects of medication administration, often providing data feedback, personalized recommendations, or secure logging.

Self-contained or portable units designed for maintaining specific temperatures for food, beverages, or sensitive items during transport, often incorporating active cooling or smart monitoring features.

Mechanical or electromechanical systems designed for precise, often self-administered, delivery of medicaments, including features for dose setting, needle insertion/retraction, and safety mechanisms to prevent premature activation.

Non-traditional refrigeration and heat pump systems that utilize principles other than vapor compression, such as magnetocaloric effects, thermoelectric effects, absorption cycles, or thermochemical reactions.

Systems and components designed for precise, automated manipulation, transfer, and dispensing of liquid samples and reagents, often involving pipettes, robotic arms, and specialized sample containers.

Use of specialized materials and structures, such as vacuum insulation panels or phase change materials, to improve thermal efficiency and maintain stable temperatures within refrigeration appliances.

Devices that assist in the physical modification or mixing of medications prior to administration, such as crushing solid drugs, cutting pills, reconstituting lyophilized products, or extracting from other devices.

Novel designs and configurations for heat exchangers that improve heat transfer efficiency, compactness, or enable specific phase change or separation processes within refrigeration and heat pump cycles.

Systems and methods for non-invasive or minimally invasive collection and analysis of physiological data (e.g., blood pressure, electrolytes, genetic markers, B cell repertoire) to assess patient health status, screen for conditions, or aid in diagnosis.

Heat transfer devices that utilize the phase change of a working fluid (evaporation and condensation) to efficiently move heat, often incorporating capillary structures, heat pipes, or vapor chambers.

Techniques and mechanisms to optimize the performance, energy consumption, and operational range of compressors in refrigeration and heat pump systems, often involving variable control of compression parameters like volume ratio or speed.

Methods and reagents designed to improve the specificity, efficiency, or yield of nucleic acid capture, ligation, amplification, or library preparation steps, particularly for sequencing applications or quantitative analysis.

Methods and kits for amplifying nucleic acids at a constant temperature, enabling faster results and point-of-care applications, often used for pathogen or contamination detection.

Development of novel materials, surface patterns, or structural supports designed to enhance cell adhesion, proliferation, differentiation, or tissue formation, including hydrogels and patterned surfaces.

Design of refrigerator interiors with reconfigurable, detachable, or specialized compartments, bins, and accessories to optimize storage, organization, and accessibility of items.

Methods and apparatus specifically tailored for the expansion, differentiation, or genetic modification of cells for therapeutic applications (e.g., CAR T cells, progenitor cells) or for the production of specific biological products (e.g., cultured fat, RNA).

Systems for precisely directing and controlling chilled air within a refrigerator, often creating distinct temperature zones or optimizing cooling efficiency for different compartments.

Integrated systems within refrigerators for dispensing chilled water, ice, or preparing beverages, often including filtration, storage components, and user interface controls.

Development of devices and methods for non-invasive or minimally invasive collection and analysis of physiological data, often from wearable sensors, to monitor health, activity, or specific conditions.