PNEUMA RESPIRATORY, INC.

An ejector mechanism of a droplet delivery device includes a piezoelectric actuator coupled to an acoustic horn and an aperture plate including a plurality of openings. At least the fluid entrance side of one or more of the plurality of openings is configured to provide a surface contact angle of less than 90 degrees and the piezoelectric actuator is operable to oscillate the aperture plate at a frequency to thereby generate an ejected stream of droplets such that at least about 50% of the droplets have an average ejected droplet diameter of less than about 6 microns during use. A sealing mechanism is provided at an interface of the aperture plate and a detachable fluid cartridge.

A method of treating a lead zirconium titanate ceramic transducer, such as for use in droplet delivery devices, includes washing the lead zirconium titanate ceramic transducer with an HCl solution and coating the transducer with material that prevents lead from leaching into fluid contacting the transducer.

An aerosol generation device includes a circuit or microcontroller for detecting and adjusting vibration frequency of an electronic transducer to a determined resonance frequency that changes during operation of the device.

A method of aerosol generation includes operating an electronic transducer at a second higher frequency than a first lower frequency with a same fluid composition and same ejector mechanism mesh with a predetermined hole size and generating smaller droplets at the second higher frequency.

A method for controlling dosing of droplet delivery device includes providing a droplet delivery device, such as an inhaler, to a user, verifying a location of the user with the droplet delivery device, such as by GPS, and enabling dosing of the drug in droplets ejected from the device based on the verifying of the location of the user.

A droplet delivery device, such as for providing aerosol to the respiratory system of an individual via inhalation, including includes an ejector mechanism in fluid communication with a reservoir that provides a constant fluid supply so that the droplet delivery device can be used to administer droplets in the device airflow in multiple orientations.

An electronically actuated droplet delivery device includes a housing with an airflow exit at a mouthpiece and an airflow entrance in fluid communication with the airflow exit via an airflow channel. An aperture plate coupled to an electronic actuator energized by a power source produces a droplet plume from a fluid reservoir in fluid communication with the aperture plate. A change of airflow trajectory in the airflow channel and/or a fan provides inertial filtering and removal of droplets in the plume that have a mass mean aerodynamic diameter greater than 5 μm.

An aerosol delivery device includes a piezoelectric transducer that is indirectly coupled to an ejector plate, such as by a membrane between the transducer and ejector plate. A spring force is applied between the ejector plate and transducer in different configurations by a suspension gasket, a compression spring, or flat spring. The spring force optimizes the production and ejection of droplets from fluid supplied to the ejector plate when the transducer vibrates to produce aerosol from the device.

A droplet delivery device, such as for providing an aerosol for inhalation by users, includes a piezoelectric transducer that vibrates an ejector plate of an ejector mechanism. The device delivers fluid to the ejector plate that is converted to droplets that exit the device as an aerosol. A highly efficient driving circuit is provided that can precisely change the peak-to-peak voltage to the transducer and frequency while also monitoring the current from a stable voltage. Precision control while monitoring the power consumption from the piezoelectric transducer allows for consistent dosing and for the user to tailor their aerosol delivery to their preferences.

A droplet delivery device includes a housing with a mouthpiece port or outlet from a nasal device for releasing fluid droplets, a fluid reservoir, and an ejector bracket having a membrane positioned between a mesh with a plurality of openings and a vibrating member that is coupled to an electronic transducer, such as an ultrasonic transducer. The transducer vibrates the vibrating member which causes the membrane to push fluid supplied by the reservoir through the mesh to generate droplets in an ejected stream released through the outlet.