Rensselaer Polytechnic Institute

Systems and methods that use imaging technologies, computer vision, and augmented reality to provide real-time guidance, localization, and visualization during surgical procedures or for detailed anatomical assessment.

Methods and compositions for identifying, quantifying, or characterizing specific biological molecules (e.g., nucleic acids, proteins, metabolites, antibodies) or microbial species, often for diagnostic, prognostic, or quality control applications.

Utilizing machine learning, particularly deep learning, to analyze medical data such as images, sensor readings, or physiological signals for disease prediction, diagnosis, or treatment assessment.

Development of materials with tailored porosity, surface chemistry, or structure, such as metal-organic frameworks (MOFs), zeolites, or superficially porous particles, for selective adsorption, ion exchange, or chromatographic separations.

Methods and systems for the efficient and scalable production, purification, and formulation of proteins and peptides, including fermentation, chromatography, and cell-based expression systems.

Techniques for manufacturing thin polymer layers, sheets, or multi-layer structures, often optimized for specific properties such as flexibility, barrier function, filtration, or mechanical strength.

Methods for training machine learning models across multiple decentralized devices or servers while keeping data localized, often involving aggregation of model parameters and secure communication.

Techniques utilizing deep learning models like Generative Adversarial Networks (GANs) or diffusion models to create new images, modify existing ones, or generate synthetic data based on various inputs or conditions.

Polymer compositions tailored for medical and biological applications, including implantable devices, drug delivery systems, and diagnostic tools, emphasizing properties like biocompatibility, hydrolysis resistance, optical clarity, and specific mechanical characteristics.

Development and application of polymer compositions designed for reprocessability, recyclability, or incorporating sustainable additives, often featuring reversible bonds or bio-based components.

Techniques for generating human-like text or other content using large pre-trained models, often involving prompt engineering, speculative decoding, or multi-modal inputs for content creation.

Delivery systems specifically engineered to administer advanced drug formulations (e.g., microparticles, biologics, extended-release systems) to achieve precise targeting, controlled release kinetics, or enhanced therapeutic efficacy within the body.

Development of therapeutic approaches involving the genetic modification of cells (e.g., T cells, stem cells, macrophages) or the use of viral/non-viral vectors to deliver genetic material for disease treatment.

Polymer compositions designed to change their properties (e.g., shape, optical transmittance, solubility) in response to external stimuli such as pH, temperature, light, or chemical presence, enabling applications in sensors, smart windows, or controlled release.

Modification of protein or peptide sequences, structures, or post-translational modifications (e.g., glycosylation, lipidation) to enhance their stability, solubility, delivery, or therapeutic efficacy.

Therapeutic strategies employing nucleic acids (DNA, RNA, oligonucleotides) to modulate gene expression, deliver genetic material, or interfere with disease-causing pathways. Includes gene therapy using viral vectors.

Membrane and depth filtration for industrial separation, gas purification, and bioprocess clarification including cross-flow, dead-end, tangential flow filtration, and oil/water separation.

Technologies and materials for capturing carbon dioxide from gas streams and subsequently converting it into valuable chemical products or materials, rather than simply storing it.

Methods and systems for improving the quality of video streams, generating intermediate frames, or continuously locating and following objects within a sequence of images, even under occlusion.

Design and synthesis of acyclic or carbocyclic organic compounds that selectively modulate specific biological targets or pathways for the treatment of diseases.

Systems and methods for automating the lifecycle of machine learning models, including pipeline deployment, model management, versioning, and configuring for different inference environments.

Design and application of devices that are inserted into the body or implanted to treat diseases, modulate physiological functions, or repair anatomical structures.

Development of devices and methods for non-invasive or minimally invasive collection and analysis of physiological data, often from wearable sensors, to monitor health, activity, or specific conditions.

Methods and catalyst systems, often supported (e.g., on silica or alumina), for the synthesis of polyolefins like polyethylene and polypropylene, focusing on controlling molecular weight, distribution, and polymer morphology.

Design and modification of antibodies or antibody-derived fragments for targeted therapeutic intervention, including bispecific formats, Fc region modifications, and activatable constructs.

Processes for creating or manipulating three-dimensional digital representations of objects or environments, including mesh generation, surface fitting, and depth estimation from multiple views.

Focuses on the design of medical equipment for ease of use, mobility, and adaptability in various clinical or home environments, including carts, mounting systems, and compact form factors.

Methods for creating fine polymer particles, powders, or microspheres with controlled size, morphology, and distribution, used as raw materials or for specific applications.

Novel methods and reactor designs for polymer synthesis, focusing on improving efficiency, achieving continuous production, or controlling specific polymer architectures and product morphologies like particle size or sheet formation.

Active anode materials and manufacturing techniques for rechargeable lithium-ion batteries, including silicon-carbon composites, graphite, lithium-metal anodes, and electrode coating processes that improve capacity, cycle life, and rate capability.