RIKEN

Provided is a cell culture vessel which allows resolution to be high in a Z-axis direction. A cell culture vessel ( 1 ) for accommodating a cell or cell tissue therein includes: a frame part ( 11 ) which is provided so as to be located at positions that correspond to respective sides of a polyhedral shape; a window part ( 12 ) which is light-transmissive and which is provided so as to be located at positions that correspond to a respective plurality of faces out of faces of the polyhedral shape; and a shaft part ( 17 ) which extends, from any of vertices of the polyhedral shape, outward in a direction that is not parallel to any of lines normal to the faces of the polyhedral shape.

An enzyme measurement method including preparing a mixed liquid including an enzyme and a selective substrate for the enzyme; preparing a microchamber array with immobilized metal nanostructures, the microchamber array having multiple microchambers in which metal nanostructures are immobilized; sealing each of the plurality of microchambers with the mixed liquid so that one or fewer molecules of the enzyme is present in each of the multiple microchambers; and illuminating the microchamber array with immobilized metal nanostructures with excitation light, and measuring the number of microchambers where a surface-enhanced Raman scattering intensity derived from an enzyme reaction product of the selective substrate or from the selective substrate has changed to a preset value or more, or is a preset threshold value or more or the threshold value or less.

An ophthalmic information processing apparatus includes a determiner and a detector. The determiner is configured to determine a presence or absence of a disc hemorrhage for a front image of a fundus of a subject's eye, using a disc hemorrhage determination model obtained by performing machine learning using a plurality of fundus images labeled with labels indicating the presence or absence of a disc hemorrhage as first teaching data. The detector is configured to detect a disc hemorrhage region depicted in the front image that is determined to have the disc hemorrhage, using a disc hemorrhage region detection model obtained by performing machine learning using a plurality of pairs of image groups as second teaching data, each pair having a front image of a fundus and a disc hemorrhage region image representing a disc hemorrhage region depicted in the front image.

According to a medical system of an aspect example, an ophthalmic data acquiring unit includes at least one ophthalmic examination apparatus for acquiring ophthalmic data from a patient, and an internal medicine data acquiring unit includes at least one internal medicine examination apparatus for acquiring internal medicine data from the patient. An inference processor is configured to perform inference processing using a trained model constructed by machine learning using training data that includes ophthalmic data, internal medicine data, and diagnostic result data. The inference processor generates inferred diagnostic data by performing the inference processing based at least on the ophthalmic data of the patient acquired by the ophthalmic data acquiring unit and the internal medicine data of the patient acquired by the internal medicine data acquiring unit. An output unit outputs a result of the inference processing performed by the inference processor.

Provided is a deep ultraviolet LED having an improved light extraction efficiency (LEE). The deep ultraviolet LED with an emission wavelength λ includes, in order from an opposite side of a substrate: a p-type electrode layer made of indium tin oxide (ITO); a p-GaN contact layer; a p-AlGaN layer transparent to the wavelength λ; an electron barrier layer transparent to the wavelength λ; a multi-quantum well layer transparent to the wavelength λ; and a n-AlGaN layer transparent to the wavelength λ. The deep ultraviolet LED includes a photonic crystal periodic structure having a plurality of pillars within a range in a thickness direction from an upper portion of the p-type electrode layer to an inside of the n-AlGaN layer, in a direction of the substrate. The photonic crystal periodic structure has a photonic band gap that is open to a TM polarized component. A period a of the photonic crystal periodic structure satisfies a Bragg condition (m×λ/n eff =2a, m: order, n eff : effective refractive index of the photonic crystal periodic structure) with respect to a light with the wavelength λ, the order m satisfies 3≤m≤7, and a radius R of the pillar satisfies 0.25≤R/a≤0.35.

Provided is an LED which has a quantum well structure, including: a quantum well layer which has a composition of Al a Ga 1-a N (aluminum gallium nitride) (0<a<1); and a high level layer which has a composition of Al b Ga 1-b N (a<b≤1), is adjacent to the quantum well layer, and has a higher energy level than that of the quantum well layer, in which ΔX, which is a difference between the a and the b, and a width D (nm) of the quantum well layer satisfy (Relational Expression 1) D=k/ΔX (where, in Relational Expression 1, D>3, 0<ΔX<0.15, and 0.45≤k≤1.25 (a unit of coefficient k is (nm))).

The present disclosure provides a method for screening cells, the method including a step of preparing a plurality of cells which are tagged with a first barcode nucleic acid associated with a test target and treated with the test target, a step of sorting the plurality of cells based on cellular phenotype using an imaging cell sorter, and a step of identifying the test target used to treat each cell using the first barcode nucleic acid as an indicator.

Provided is a novel fluorescent probe. A compound of the following general formula (I) or a salt thereof.

A factor parameter for estimating a label of a target from a plurality of parameters that can be acquired for the target. In a suggestion device, a calculator learns, by referring to a plurality of records in which each record represents a plurality of parameter values acquired from the target and a label provided to the target, an estimation model that estimates a label from a parameter related to a combination for a part of calculation candidates among a plurality of candidates representing a combination of parameters; calculates performance of the estimation model; causes calculation candidates to compete based on the calculated performance; and calculates a rating value of the calculation candidate. An estimator learns a rating model by a rating value and a combination of parameters of the calculation candidate, and estimates a rating value of an estimation candidate other than the calculation candidate. An outputter outputs, as a useful candidate representing a factor parameter, a candidate having a calculated or estimated high-ranking rating value and being the calculation candidate.

Maintainability is to be improved. A radio frequency quadrupole linear accelerator includes a tubular housing part having an outer peripheral surface at which two pairs of openings extending in an axial direction are formed facing each other, and a plurality of first vane electrodes inserted into the respective openings of the tubular housing part from outside toward an axial center, detachably attached to the openings, and disposed facing each other.