SEKISUI MEDICAL CO., LTD.

A problem to be solved is to provide a test strip capable of avoiding occurrence of a so-called bleaching phenomenon in an immunochromatographic test strip to enable better detection and visibility. Another problem to be solved is to provide an immunochromatographic test strip capable of preventing a variation in detection value on a test line. The problems are solved by an immunochromatographic test strip including at least a porous membrane and having a sample application region, a development region, and a detection region in which a specific binding substance is immobilized, wherein the detection region is immobilized on a front surface of the porous membrane, and wherein an opaque base material having a thickness of 30 μm or more and 200 μm or less is placed on the back surface of the porous membrane.

A method for producing a ketimine compound of formula (3) in which one to five of R 1b to R 5b each represent hydroxyalkyloxy having 1-16 carbon atoms, the remaining groups each represent hydrogen or halogen, for example, and R B represents hydrogen, hydroxy, or alkoxy having 1-6 carbon atoms, for example), wherein a silazane compound is subjected to a reaction with a benzoyl compound of formula (2) in which R 1b to R 5b and R B are as described above)), and then the resulting product is subjected to a reaction with an acid or a base.

Provided is a blood collection container capable of increasing a recovery amount of mononuclear cells. A blood collection container includes a blood collection container main body; a specific gravity liquid contained in the blood collection container main body; and a blood separation material contained in the blood collection container main body, in which the specific gravity liquid contains an amino acid.

Provided is a blood coagulation time measurement method. In the method, reaction X(i) is acquired through smoothing and zero-point adjustment of a measured value P(i) for coagulation reaction of a blood specimen, and then an integration ratio Z(i) of the reaction X(i) is acquired. These values are used to calculate an index for coagulation time Tc calculation, and it is determined whether or not the index satisfies the criteria. The procedure is sequentially repeated until an index that satisfies the criteria is obtained.

To provide synthesis method where efficiencies of Fmoc amino acid condensation reaction and deFmoc reaction are not impaired without additional solvent, in synthesis of peptide by using certain number of hydrophobic amino acids and amino acid having functional group in its side chain or long-chain peptide. Method for synthesizing peptide comprising one or more amino acid having functional group in its side chain, 50% or more of hydrophobic amino acid, and 10% or less of amino acid wherein the α-amino group is secondary amino group; or peptide comprising one or more amino acid having functional group in its side chain and having 21 or more of amino acid residues, wherein the carrier for peptide synthesis of Formula (1) is introduced into the side chain of the amino acid having functional group in its side chain.

A blood coagulation time shortening agent for a blood specimen deficient in coagulation factor XII, in activated partial thromboplastin time measurement includes, as an active ingredient, a polymer having 2-methacryloyloxyethyl phosphorylcholine as a constitutional unit.

An activated partial thromboplastin time measurement reagent contains a polymer having 2-methacryloyloxyethyl phosphorylcholine as a constitutional unit. A blood coagulation time regulator for a lupus anticoagulant-positive blood specimen or a heparin-containing blood specimen in activated partial thromboplastin time measurement includes, as an active ingredient, a polymer having 2-methacryloyloxyethyl phosphorylcholine as a constitutional unit.

A problem to be solved is to provide a test strip capable of avoiding occurrence of a so-called bleaching phenomenon in an immunochromatographic test strip to enable better detection and visibility. Another problem to be solved is to provide an immunochromatographic test strip capable of preventing a variation in detection value on a test line. The problems are solved by an immunochromatographic test strip including at least a porous membrane and having a sample application region, a development region, and a detection region in which a specific binding substance is immobilized, wherein the detection region is immobilized on a front surface of the porous membrane, and wherein an opaque base material having a thickness of 30 μm or more and 200 μm or less is placed on the back surface of the porous membrane.

An automatic analysis apparatus is capable of stirring a reagent without reducing the analysis processing capacity. The automatic analysis apparatus includes a reagent table that is rotatable and that holds reagent vessels, and a plurality of magnets are disposed below the reagent table, with orientations of magnetic poles of the magnets fixed, along a movement path of the reagent vessels moving on a circumference when the reagent table is rotationally driven. The plurality of magnets is disposed such that the fixed orientations of the magnetic poles of the magnets vary along the movement path, and act a magnetic force on a stirring bar in each of the reagent vessels. When the reagent table is rotated and the reagent vessels pass above the magnets, the stirring bar in each of the reagent vessels is rotated or oscillated by the magnetic force received from the magnets, to stir the reagent.

A method for measuring an oligonucleotide which is simpler and more sensitive and has excellent specificity and quantitative capability compared to a conventional measurement method is provided. Moreover, a method for measuring an oligonucleotide having excellent specificity which can distinguish the intact target oligonucleotide (unchanged material) and a metabolite thereof and detect the unchanged material only is provided. In a hybridization method using a capture probe and an assist probe, using a capture probe and an assist probe having short nucleotide length in certain ranges, especially an assist probe having a short nucleotide length in a certain range which is generally unexpected, and by causing hybridization of the site of the nucleotide(s) lacking in a metabolite of a nucleic acid drug and the assist probe at a specific positional relationship, it becomes possible not only to detect the target oligonucleotide in a sample but also to distinguish from a metabolite of a nucleic acid drug.