Senseonics, Incorporated

A sensor (e.g., an analyte sensor) that may be implanted partially or fully within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a housing, a first polymer that includes analyte indicator molecules and covers at least a portion of the housing, and a second polymer that forms an interpenetrating network with the first polymer. The second polymer may prevent biological or protein interference of the sensor.

An apparatus (e.g., an analyte sensor) may include an energy storage device, first circuit components, second circuit components, an antenna, a rectifier, and a power switch. The antenna may be configured to generate an alternating current when in an electromagnetic field. The rectifier may be configured to convert the alternating current to direct current. The power switch may be configured to disconnect the energy storage device from the first and second circuit components such that current cannot leak from the energy storage device to the first and second circuit components. The power switch may further be configured to connect the rectifier to the first circuit components in an energy storage device disabled state and connect the energy storage device to at least the second circuit components in an energy storage device enabled state.

Apparatuses, systems, and methods for autonomously-initiated analyte measurements and/or calculation of analyte concentrations based on the analyte measurements. An apparatus (e.g., an analyte sensor or a sensing device of the analyte sensor) may be configured to take and sets of sensor measurements at a first frequency having a period equal to a threshold number of cycles of the clock. The stored sets of sensor measurements may include first sets of sensor measurements at the first frequency and second sets of sensor measurements at a second frequency, and the first frequency is greater than the second frequency. Another apparatus (e.g., a transceiver, display device, and/or data management system) may be configured to receive sets of sensor measurements conveyed by the analyte sensor, calculate time stamps for the sets of sensor measurements, and calculate analyte concentrations based on the sets of sensor measurements and the calculated time stamps.

Apparatuses, systems, and methods for calculating and selecting between multiple streams of analyte levels. The method may include using first and second methods to calculate streams of first and second analyte levels for multiple instances of time based on at least sensor data for the multiple instances of time. The method may include using the stream of first analyte levels for display and determining whether to switch from use of the stream of first analyte levels for display to use of the stream of second analyte levels for display, which may include comparing one or more of the first analyte levels to one or more of the second analyte levels. The method may include continuing to use the stream of first analyte levels for display or switching to use of the stream of second analyte levels for display depending on the determination of whether to switch.

Apparatuses, systems, and methods for autonomously-initiated analyte measurements and/or calculation of analyte concentrations based on the analyte measurements. An apparatus (e.g., an analyte sensor or a sensing device of the analyte sensor) may be configured to take and sets of sensor measurements at a first frequency having a period equal to a threshold number of cycles of the clock. The stored sets of sensor measurements may include first sets of sensor measurements at the first frequency and second sets of sensor measurements at a second frequency, and the first frequency is greater than the second frequency. Another apparatus (e.g., a transceiver, display device, and/or data management system) may be configured to receive sets of sensor measurements conveyed by the analyte sensor, calculate time stamps for the sets of sensor measurements, and calculate analyte concentrations based on the sets of sensor measurements and the calculated time stamps.

A device including a core and a printed circuit board (PCB) including a circuit portion and an antenna portion. The circuit portion may include one or more circuit components. The one or more circuit components may include measurement electronics and a measurement controller. The antenna portion may include a flexible substrate and an antenna. The antenna portion may be configured to wrap around the core. The device may include a housing. The PCB and the core may be located within the housing. The antenna portion of the PCB may be configured to unroll such that, after the PCB is inserted within the housing, at least a portion of the antenna portion is in contact with an internal surface of the housing.

A sensor may include a substrate and an array of photodetectors mounted on or fabricated in the substrate. The array may include first photodetectors configured to detect light in a first wavelength range and second photodetectors configured to detect light in a second wavelength range that is different from the first wavelength range. The first photodetectors may be spatially distributed the array of photodetectors, and the second photodetectors may be spatially distributed spatially distributed throughout the array of photodetectors. One or more light sources may be mounted on or fabricated in the substrate. The one or more lights sources may be interleaved with the photodetectors, or the first and second light emitting active areas of first and second light sources may be co-located.

A sensor, system, and method for detecting and correcting for an effect on an analyte indicator of an analyte sensor. The analyte indicator may have a first detectable property that varies in accordance with an analyte concentration and an effect on (e.g., degradation of) the analyte indicator. The analyte sensor may also include an interferent indicator having a second detectable property (e.g., absorption) that varies in accordance the effect on the analyte indicator. The analyte sensor may generate (i) an analyte measurement based on the first detectable property of the analyte indicator and (ii) an interferent measurement based on the second detectable property of the interferent indicator. The analyte sensor may be part of a system that also includes a transceiver. The transceiver may use the analyte and interferent measurements to calculate an analyte level.

An analyte monitoring system, which includes an analyte sensor, may perform a method including generating first, second, and third sets of one or more analyte values using first, second, and third measurement electronics, respectively, of first, second, and third sensing areas (SAs), respectively, of the analyte sensor. The first, second, and third SAs may be different. The method may include determining a distribution value based on a plurality of sets of analyte values including the first, second, and/or third sets of analyte values, and the distribution value may indicate a distribution of the plurality of sets of analyte values. The method may include determining a combined analyte level based at least on the plurality of sets of analyte values and the distribution value.

Systems and apparatuses for near field communication with a receiver. An apparatus may include an antenna and one or more antenna printed circuit boards. The antenna may include first conductors in a first antenna layer and second conductors in one or more second antenna layers. A current supplied to the antenna may pass through the first conductors in a direction opposite to a direction through which the current passes through the second conductors. A system may include the apparatus and the receiver, which may include a receiver coil. The opposite directions through which the current passes through the first and second conductors may be substantially perpendicular to a longitudinal axis of the receiver coil. The antenna may generate a substantial magnetic flux that is a direction corresponding to the longitudinal axial of the receiver coil, which may be oriented parallel to a flat surface of the antenna.