SHEBA IMPACT LTD.

Provided herein are compositions comprising isolated T cells specific for one or more viral antigens derived from viruses such as adenovirus (ADV), cytomegalovirus (CMV), BK virus (BKV), Epstein-Barr virus (EBV), human herpes virus 6 (HHV6), John Cunningham virus (JC), or human immunodeficiency virus (HIV), methods for obtaining them, libraries including them, and uses thereof in treating viral infections.

The present application provides a system for determining a dosage of a diuretic required by a subject suffering from or at risk of heart failure, which facilitates a “closed loop” of measuring urinary parameters and treating. The system comprises at least a sodium measurement sensor, such as a chemo-electrical sensor, for measuring urinary sodium levels, and one or more processors, configured to receive the measured urinary sodium levels; calculate a subject-optimized dosage of the diuretic based on the measured urinary sodium levels, optionally using a machine learning algorithm; and provide an output comprising the calculated subject-optimized dosage of diuretic. The present application further comprises methods of using the system.

Apparatus and methods are described for use at an atrioventricular valve of a heart of a subject, the atrioventricular valve including a valve annulus, valve leaflets, chords, and papillary muscles. An annuloplasty ring is configured to be implanted on an atrial side of the atrioventricular valve. A plurality of chord-manipulation arms are configured to be deployed among the chords of the atrioventricular valve, and, subsequently, in response to being rotated, to cause a size of the valve annulus to decrease, by twisting the native atrioventricular valve and pulling the native atrioventricular valve radially inwards, by the chord-manipulation arms deflecting the chords. Subsequently, the chord-manipulation arms are configured to provide a counterforce against which the annuloplasty ring can be pushed, during implantation of the annuloplasty ring. Other applications are also described.

There is provided a method of reconstruction of a target brain structure(s), comprising: reconstructing at least a part of a brain comprising boundaries of brain structures that include the target brain structure(s), wherein the reconstruction is insufficient for parceling of the target brain structure(s) into sub-structures of a same type of gray or white matter, reconstructing and parceling the target brain structure(s) using a reference atlas, segmenting and parceling at least one originating brain structure using the reference atlas, filtering white matter fibers to isolate at least one target white matter tract connecting the originating brain structure(s) and the target brain structure(s), and creating a 3D reconstruction of the target brain structure(s) and the target white matter tract(s), wherein the target white matter tract(s) and the target brain structure(s) are transformed and/or mapped to an anatomical native space.

A medical diagnostic device may include: an annular body having a proximal end, a distal end, a central longitudinal axis and a hollow interior, and wherein the distal end is configured to be inserted into a bodily orifice of a subject; a base connected to the proximal end of the annular body adapted to be held by hand of the subject and having a hollow interior; a first imaging device insertable at the distal end of the annular body, wherein the first imaging device is configured to obtain one or more images of an internal environment of the bodily orifice of the subject; and a second imaging device insertable into the hollow interior of the base, wherein the second imaging device is configured to obtain one or more images of an external environment of the bodily orifice of the subject.

The invention provides assays and methods for analyzing inflammatory disorders of the gastrointestinal (GI) tract. Provided in embodiments of the invention are host transcriptome markers and classifiers amenable for assessing and monitoring the existence, severity and location of inflammation associated with inflammatory bowel disease (IBD), Crohn's disease (CD) and Ulcerative colitis (UC). Further provided are improved protocols for processing and analyzing fecal samples, providing superior non-invasive means for evaluating GI inflammation.

Disclosed herein are receive-only network devices and methods for use for securely identifying a network. The receive-only network device comprised a network physical layer (PHY) circuit configured to establish a physical layer connection to a network via one or more wired transmission mediums and a controller electrically coupled to a receive channel of the PHY via a unidirectional hardware buffer configured to transfer electronic signals received from the PHY and block electronic signals received from the controller. The controller is configured to receive from the PHY one or more link layer frames transmitted by one or more network controllers of the network and intercepted by the PHY, extract one or more network attributes of the network from the one or more intercepted link layer frames, identify the network at least partially according to the one or more extracted network attributes, and present the identity of the network to a user.

Apparatus and methods are described for use with an annuloplasty ring ( 20 ), and an atrioventricular valve of a heart of a mammalian subject, the atrioventricular valve including a valve annulus, valve leaflets, chords, and papillary muscles. A plurality of chord-manipulation arms ( 26 ) are configured to be deployed among the chords of the atrioventricular valve, and to cause a size of the valve annulus to decrease, by the chord-manipulation arms ( 26 ) being rotated such as to twist the native atrioventricular valve and pull the native atrioventricular valve radially inwards, by the chord-manipulation arms ( 26 ) deflecting the chords. The chord-manipulation arms ( 26 ) are configured to subsequently provide a counterforce against which the annuloplasty ring ( 20 ) is pushed, during implantation of the annuloplasty ring ( 20 ). Other applications are also described.

Apparatus and methods are described herein including an expandable prosthetic mitral valve device that includes a first component configured to be deployed in the left atrium of a subject and a second component configured to be deployed in a left ventricle of the subject. At least one approximating component approximates the first and second components with respect to each other, such that, when the first and said second components are in an approximated configuration with respect to each other, one or more leaflets of the native mitral valve are trapped within the gap between a ventricular part and an annulus part. The approximating component secures the annulus part and the ventricular part in the approximated configuration. Other applications are also described.

The present invention provides methods and compositions comprising essential oil extracted from Pelargonium graveolens for treating, preventing, or ameliorating traumatic brain injury (TBI) in a subject, or for improving cognitive functions in a subject suffering from TBI.