Synaptive Medical Inc.

A visualization system and methods for simultaneously visualizing white light and visible fluorescent light, the visualization involving an illumination system and an imaging system operable with the illumination system. The illumination system has a light source produces illumination light (white light and fluorescence excitation light), an optical notch rejection filter to remove light having peak fluorescence excitation wavelengths from the illumination light, and illumination optics to at least one of deliver and condense the filtered illumination light. The imaging system has imaging optics, a fluorescence excitation light removal filter to remove excitation light from the imaged light, a beam splitter to split the filtered images light into a first beam (white light), and a second beam (fluorescent imaging light), an optical notch rejection filter to ensure that light, having peak fluorescence emission wavelengths of a fluorophore, does not reach a white light camera, an optical notch pass filter to pass only the fluorescent imaging light component, a camera to image the white light; and another camera to image the fluorescent light.

Imaging systems and methods of multiple fluorophore visualization involving a videoscope. According to embodiments of the disclosure simultaneous visualization of each fluorophore the spatial distribution of fluorophores could be separately visualized by fusing the images and colouring each fluorophore differently. The distribution of each fluorophore could allow for Boolean logic on the fluorescence singles where the combination of fluorophores detected in each pixel is indicative of the state of the tissue.

A surgical imaging system is described. The system includes first and second optical assemblies. Each optical assembly defines a respective optical axis, and each includes a respective set of one or more optics for adjusting field-of-view (FOV) and focus and a respective camera for capturing an image. The system includes a controller for controlling the optical assemblies and for switching the surgical imaging system between a coupled configuration and an uncoupled configuration. In the coupled configuration, the first optical assemblies are controlled to adjust the respective sets of optics and/or the respective optical axes in dependence on each other. In the uncoupled configuration, the optical assemblies are controlled to adjust the respective sets of optics, and the respective optical axes independently of each other.

An optical imaging system for imaging a target during a medical procedure, the optical imaging system involving a first camera for capturing a first image of the target, a second wide-field camera for capturing a second image of the target, at least one optional path folding mirror disposed in an optical path between the target and a lens of the second camera, and a processor for receiving the first image and the second image, the processor configured to apply an image transform to one of the first image and the second wide-field image and combine the transformed image with the other one of the images to produce a stereoscopic image of the target.

Systems and methods for magnetic resonance imaging (“MRI”) of multiple different nuclear spin species using the same radio frequency (“RF”) coil are described. Generally, multiple different nuclear spin species are imaged using the same RF coil by using an MRI system whose magnetic field can be rapidly ramped between a number of different, and arbitrary, magnetic field strengths. The magnetic field of this MRI system can be ramped to different values in reasonable amounts of time (e.g., in a time frame that is feasible within an imaging study).

A surgical camera system, and method therefor, is provided which includes a plurality of imaging devices each having a tunable iris configured to change between at least two different sized numerical apertures.

Imaging systems and methods involving a videoscope including cameras; a filter feature in optical communication with the cameras, the filter feature configured to independently filter or tandemly filter light from each camera; an independently adjustable aperture in optical communication with the filter feature, the independently adjustable aperture configured to limit transmission of filtered light; independently adjustable zoom features in optical communication with the independently adjustable aperture, the independently adjustable zoom features including corresponding independently adjustable zoom channels, and each independently adjustable zoom feature configured to independently zoom independently limited filtered light; a prism in optical communication with the independently adjustable zoom channels, the prism configured to redirect independently zoomed, independently limited, filtered light; and a shared focus feature in optical communication with the prism, the shared focus feature comprising a shared focus channel, and the shared focus feature configured to focus redirected, independently zoomed, independently limited, filtered light.

An optical imaging system for imaging a target during a medical procedure, the optical imaging system involving a first camera for capturing a first image of the target, a second wide-field camera for capturing a second image of the target, at least one optional path folding mirror disposed in an optical path between the target and a lens of the second camera, and a processor for receiving the first image and the second image, the processor configured to apply an image transform to one of the first image and the second wide-field image and combine the transformed image with the other one of the images to produce a stereoscopic image of the target.

Systems and methods for adaptive, multi-resolution magnetic resonance imaging (“MRI”), in which an MRI scan prescription is adaptively changed to acquire high-quality data from select regions-of-interest (“ROI”) in a larger field-of-view (“FOV”), are provided. The higher quality data can include data representing higher spatial resolution, higher signal-to-noise ratio (“SNR”), increased diffusion encoding via repeated acquisition with a larger number of diffusion-encoding directions, and so on. A composite image can be generated that displays the higher quality images of the ROIs overlaid on the larger FOV.

A multispectral synchronized imaging system is provided. A multispectral light source of the system comprises: blue, green and red LEDs, and one or more non-visible light sources, each being independently addressable and configured to emit, in a sequence: at least visible white light, and non-visible light in one or more given non-visible frequency ranges. The system further comprises a camera and an optical filter arranged to filter light received at the camera, by: transmitting visible light from the LEDs; filter out non-visible light from the non-visible light sources; and otherwise transmit excited light emitted by a tissue sample excited by non-visible light. Images acquired by the camera are output to a display device. A control unit synchronizes acquisition of respective images at the camera for each of blue light, green light, visible white light, and excited light received at the camera, as reflected by the tissue sample.