The Hong Kong Polytechnic University

A novel pharmacologic treatment of refractive disorders including myopia and hyperopia is provided. The method of treating refractive disorders including myopia and hyperopia is mainly through targeting the Hippo biological pathway using agonists, antagonists or gene therapy targeting the HIPPO signaling, including MST1/MST2, LATS1/LATS2 kinases, and YAP/TAZ proteins. It is also found that the drug XMU-MP-1, a reversible and selective inhibitor of MST1/2, is a promising drug to target the Hippo biological pathway.

A method for predicting gas explosion. The method includes: obtaining a geometric model with spatial obstacles; determining a simulation dataset of the gas explosion based on the geometric model, where the simulation dataset is a dataset including process data of multiple gas explosion scenes in the geometric model, and a state vector of a spatial grid node in the simulation dataset includes a first moment, coordinate information and a target pressure value; optimizing, using the simulation dataset, a physics-informed GNN to obtain an optimized physics-informed GNN; and predicting the gas explosion in an obstructed gas explosion scenario using the optimized physics-informed GNN. This method is applied to use optimized physics-informed GNN to realize spatiotemporal second-level prediction of overpressure distribution and explosion wave propagations occurring in the obstructed gas explosion scenario, enhance the accuracy, the reliability and the efficiency of gas explosion prediction in the obstructed gas explosion scenario.

Disclosed in the present application is a wireless charging system including a wireless charger and a wireless charging remote device. The wireless charger includes: a transmitter coil, configured to transferring power wirelessly, and comprising a plurality of windings wounded in spiral shape, wherein at least one turn of the plurality of windings comprises at least one bending part to form an accommodating space; a power converting circuit, configured to provide power to the transmitter coil; and at least one mechanical support, disposed in the accommodating space and is configured to withstand significant mechanical loads.

A haptic apparatus is provided for stimulating a skin of a user to provide haptic feedback to the user. The haptic apparatus comprises an elastomeric substrate layer and multilayered electrical circuits comprising hydrogel electrodes for contacting the skin and electro-stimulating the skin to generate the haptic feedback. The multilayered electrical circuits are arranged on the elastomeric substrate layer, thereby avoiding forming the multilayered electrical circuits on a printed circuit board.

A gait event-driven, phase-dependent and multi-modal foot rehabilitation system, and a use method thereof. The system comprises: a pressure sensor module ( 110 ) which measures a pressure distribution value of a foot sole in real time; a micro-control module ( 111 ) which compares the measured pressure value with a preset threshold value to identify different gait events in a dynamic gait and a pressure balance on the inner and outer sides of the foot sole and to control a corresponding operation in real time; a neuromuscular electrical stimulation module ( 100 ) which applies or stops a suprathreshold electrical stimulation delivered to a target muscle of the foot on the basis of the recognized gait event; a combined pneumatic musculo-skeletal module ( 200 ) which comprises a pneumatic muscle ( 305 ) and deflates or inflates the pneumatic muscle ( 305 ) on the basis of the recognized gait event; and a vibratory biofeedback module ( 109 ) which, when recognizing an imbalance of pressure between the inner side and the outer side of the foot sole, provides a biofeedback to correct the imbalance of force exerted by the foot sole. The gait events comprises heel striking, heel off and sole off. The system can correct foot drop and foot varus, mitigate muscle compensation and dystrophy, and restore a normal gait.

A bio-inspired imaging device mimicking visual adaptation of human vision in imaging an image employs a neuromorphic vision sensor realized with phototransistors each being a field-effect transistor, a channel layer of which is an atomically-thin layer of two-dimensional semiconductor material. The channel layer is intentionally formed with defects trap states for trapping a portion of charge carriers generated by a light beam incident on the phototransistor such that intensity information of the light beam is memorized. A gate-source voltage directs the defects trap states to de-trap the trapped portion of charge carriers or to further trap an additional portion of charge carriers, allowing the phototransistors to exhibit a time-dependent excitation or inhibition effect on drain current to thereby enable the imaging device to mimic scotopic or photopic adaptation in imaging the image. The gate-source voltage is determined according to a background light intensity used in forming the image.

A gate drive circuit for a half-bridge power module with a first and second GaN HEMT is disclosed. The circuit mitigates gate voltage overshoot, oscillation, and crosstalk induced by high dv/dt at the switching node. It includes a voltage clamp circuit, electrically connected to the gate of the first GaN HEMT, to suppress gate voltage overshoot. A negative voltage generation and control circuit is configured to generate and apply a negative voltage to the gate to offset positive crosstalk voltage spikes. A low-impedance Miller current path circuit is connected to the gate to provide a discharge path for Miller current, thereby suppressing negative crosstalk voltage spikes. The circuit provides robust protection for GaN HEMTs operating at high switching speeds.

A spectacle lens can inhibit ametropia of the eyes and ensure full visibility. The spectacle lens comprises: first refraction areas and second refraction areas. Each first refraction area has a first refraction force that may be based on a prescription for correcting the ametropia of the eyes. Each second refraction area has a refraction force different from the first refraction force and may function to focus images on the positions except the retina of the eyes, to inhibit the development of the ametropia. Near the central part of the lens, the second refraction areas form a plurality of independent island-shaped areas, and the first refraction areas form the areas beyond the areas of the second refraction areas.

This disclosure relates to a highly integrated wireless ultrasonic motor (USM) system, comprising: a high-frequency inverter configured to convert DC power into high-frequency AC power; a first and second wireless power transfer channel connected to the inverter respectively, wherein the first wireless power transfer channel includes a first transmitting and receiving coils directly connected to a stator of the motor, and the second wireless power transfer channel includes a second transmitting and receiving coils directly connected to the stator, and wherein the stator resonates with the receiving coils when excited by a high-frequency magnetic field, generating a driving AC voltage; an autonomous optimal frequency adaptation control unit configured to detect zero-crossings of an inverter output current and to generate drive trigger commands to adjust a motor driving frequency; and a frequency-adaptive pulse step modulation (FAPSM) unit configured to dynamically adjust a pulse step amplitude and frequency of the output voltage of the inverter.

A recombinant arginine deiminase including a fluorescent group attached via an optional linker to the side chain of a cysteine residue useful for qualitative and quantitative detection of L-arginine in a sample, and methods of use and preparation thereof.