Twenty Twenty Therapeutics LLC

Systems, devices, and methods for detecting a visual indicator of an occluder for an eye examination are provided. In one example, a device may be used to administer an eye examination by detecting, via a camera of the device, a visual indicator located on an occluder while the occluder is covering at least a portion of a user's face. The device can configure a graphical user interface to display, at a display screen of the device, an eye examination administered to the user. The device can output, via the display screen, a result of the eye examination based on information encoded by the visual indicator. In some implementations, the detecting may include detecting an opaque surface of the occluder covering an eye of the user. In some implementations, the detecting may include detecting a lens of the occluder covering an eye of the user.

An intraocular implant comprising: a pressure sensor implantable in an eye, wherein the pressure sensor comprises a substrate having a first side coupled to a membrane to define an optical cavity with a depth that varies based on an intraocular pressure of the eye; and an enclosure coupled to a second side of the substrate to define a hermetic cavity comprising a light source and a detector operable to interrogate the pressure sensor and obtain data corresponding to an intraocular pressure of the eye based on the interrogation.

A system for spatially aligning an external measuring device and an intraocular implant, the system comprising: an intraocular implant configured to be implanted into an eye of a user to monitor or measure intraocular parameters; and an external measuring device configured to receive and measure the intraocular parameters when aligned with the intraocular implant, the external measuring device comprising one or more visual targets and one or more mirrors operable to align a line of sight of the eye so that the intraocular implant is aligned with a main optical path of the external measuring device for measuring.

A vitrectomy device includes a carrier having a pocket. A cover is connected to the carrier with at least one of the carrier and the cover has an axle defining an axis. A trigger is pivotably connected to the axle and having a passage. A hollow needle is provided for insertion into the vitreous humor of an eye and extends within the passage. A vacuum sample assembly is received in the pocket and has a chamber under vacuum. The trigger is pivotable about the axle from a first position in which the chamber is not fluidly connected to the needle to a second position in which the needle is bent into fluid communication with the chamber for automatically drawing a vitreous sample through the needle into the chamber under vacuum pressure. Other aspects are also described.

An intraocular pressure (IOP) measurement system comprising: an optical pressure sensor implantable in an eye, wherein the sensor has a substrate coupled to a membrane that changes shape as a function of an intraocular pressure of the eye, and the substrate and the membrane define a sealed cavity; an optical transmitter to emit an incident optical beam to the sensor; a receiver to produce an interference pattern in response to receiving a plurality of reflections of the incident optical beam from the sensor; an image sensor operable to receive a projection of the interference pattern; and a processor configured to estimate the intraocular pressure of the eye based on processing the projection of the interference pattern.

An intraocular pressure sensor implant comprising a substrate defining a surface implantable in an eye; a membrane coupled to the substrate, the membrane operable to change shape as a function of an intraocular pressure of the eye and defining an active area; and a lens coupled to the substrate, the lens operable to focus an optical beam to the active area for measurement of the intraocular pressure based on a spacing between the membrane and the surface.

A non-gravitational fluid delivery device is provided for delivering fluid to an eye of a user. The device has a cartridge including a container and a cartridge head coupled to the container. The container defines an inner container chamber configured to accommodate a fluid. The head includes opposing first and second walls collectively defining both a nozzle and a nozzle opening extending through the nozzle. The first wall is at least partially formed from a deformable material. The second wall is at least partially formed from a rigid material. Fluid is selectively delivered from the fluid delivery device to the eye through the nozzle opening. The nozzle opening extends in a fluid delivery direction between the first and second walls. The nozzle opening is selectively transitioned between opened and closed conditions via selective manipulation of the first wall.

Uniform and location patterned drug release can be achieved via microchannel(s) embedded in a drug dispensing ophthalmic device. At least one reservoir can be encapsulated within the ophthalmic device at a discrete location to hold an amount of a drug. Each reservoir can be covered by an electrode that electrodissolves to release the drug. At least one microchannel having a length and holding at least water is encapsulated in the ophthalmic device between the reservoir and the side of the ophthalmic device facing the eye. After release from the reservoir, the drug spreads through an entirety of the length of the microchannel due to a capillary force inside the microchannel and a diffusion coefficient of the drug in the water. The amount of the drug diffuses from a plurality of locations along the entirety of the length of the microchannel.

A drug dispensing ophthalmic device can be constructed from integrated modular elements. First, an integrated device can be created by mating an interconnect interface of an electronic control module (ECM) to a passive interconnect interface of a primary drug container module (PDCM) and forming an electrical connection between the interconnect interface of the ECM to the passive interconnect interface of the PDCM. Then, the integrated device can be encapsulated within a body of an ophthalmic device.

An under-lid device (ULD), at least a portion of which is coated with a hydrogel comprising hydroxypropyl methylcellulose and/or hyaluronic acid, is described. Methods of using the ULD to treat dry eye, kits for the ULD, and methods of incorporating the tear retention polymers hydroxypropyl methylcellulose or hyaluronic acid into the hydrogel are also described.