Université de Bordeaux

The invention relates to a system ( 1 ) for determining a distance between two movable elements, the system comprising a processor, an energy source and a pair of transmitting and receiving electrodes ( 41, 42 ), the energy source being configured to generate a first electric current to the transmitting electrode ( 41 ) so that the receiving electrode ( 42 ) delivers, by inductive coupling, a second electric current, in which: —the electrodes are located at less than 40 mm and include at least: o a magnetic core, o a metallic winding having an inductance ranging from 1 μH to 470 μH, —the processor ( 10 ) is configured to convert the electric current delivered by the receiving electrode ( 42 ) into an intensity value and to generate a measurement signal including the intensity value, the processor is further configured to carry out a digital processing of the measurement signal to obtain an estimate of the distance.

Computer-implemented method for estimating a respiratory rate of a subject, the method including acquiring a single-lead electrocardiographic signal from the subject, detecting R-peaks of the single-lead electrocardiographic signal, determining R-peak intervals from the R-peaks, extracting QRS complexes corresponding to the R-peaks based on the single-lead electrocardiographic signal, determining a time-domain sequence of root mean square amplitudes of the QRS complexes in a first window, the first window being in the time domain, generating, within a predetermined frequency range, a power spectrum of the sequence of root mean square amplitudes, determining a dominant frequency of the power spectrum, and estimating the respiratory rate of the subject based on the dominant frequency. Respirometry system employing same.

The present invention relates to highly pure high performance polycrystalline diamond monolith, a method for manufacturing a single-crystal diamond, and uses thereof.

An apparatus includes a shaft and an end effector at a distal end of the shaft. The end effector is sized to fit in an anatomical passageway within a subject's cardiovascular system. The end effector includes at least one electrode pair that is configured to contact cardiovascular tissue and thereby pick up electrocardiogram signals. Each electrode pair includes first and second electrodes spaced apart along a longitudinal axis from each other by a gap area located between the electrodes, the gap area having a gap length with respect to the longitudinal axis such that a length of one of the electrodes along the longitudinal axis is equal to or greater than the gap length; and a ratio of an area defined by the gap area to one electrode area is equal to or less than one.

Cerebral small vessel disease (SVD) is a leading cause of stroke and a major contributor to cognitive decline and dementia in the population. Evidences indicate that blood brain barrier dysfunction may play a significant role in VD pathogenesis. Recently, an inverse association of TRIM47 expression in brain and vascular tissues with extensive-SVD severity was reported in a human genome wide association study combined with summary-based Mendelian randomization studies and profiling of human loss-of-function allele carriers. Now, the inventors demonstrate TRIM47 is a key regulator of actin cytoskeleton organization through KEAP1/NRF2 signalling pathway and might be protective from oxidative stress in brain EC. In particular, the in vitro TRIM47 knockdown decreases directed EC migration and delays EC adhesion process with loss of actin cortical reorganization and focal adhesion contacts. Furthermore, RNA sequencing and BioID results indicate that TRIM47 knockdown in brain EC, represses the expression of genes associated with cytoskeleton and NRF2 antioxidant pathway through a potential interaction with KEAP1. Accordingly, the present invention relates to the use of Nrf2 activators for the treatment of SVD.

An imaging device ( 100 ) for observing the development of a living cell or a set of living cells such as embryos ( 80 ), comprising a lighting system ( 110 ), and an imaging system ( 120 ) equipped with a wide-field camera ( 121 ) which is adapted to allow the identification, the imaging and the observation of one or more living cells or sets of living cells ( 80 ) to be observed. The invention also relates to a method for observing the development of embryos by way of such a device ( 100 ).

An apparatus includes a shaft and an end effector at a distal end of the shaft. The end effector is sized to fit in an anatomical passageway within a subject's cardiovascular system. The end effector includes at least one electrode pair that is configured to contact cardiovascular tissue and thereby pick up electrocardiogram signals. Each electrode pair includes first and second electrodes spaced apart along a longitudinal axis from each other by a gap area located between the electrodes, the gap area having a gap length with respect to the longitudinal axis such that a length of one of the electrodes along the longitudinal axis is equal to or greater than the gap length; and a ratio of an area defined by the gap area to one electrode area is equal to or less than one.

The present invention relates to a “one-pot” method for preparing an aqueous solution of nanoparticles with amphiphilic block copolymers and comprising polypeptide units, the method comprising at least one step (E1), in an aqueous solvent, consisting of bringing together: —at least one hydrophilic polymer (P1) comprising at least one amine function, and —at least one hydrophobic α-amino acid N-carboxyanhydride monomer.

The present invention relates to tetramolecular parallel G-quadruplex-forming oligonucleotides. If G-quadruplexes are of prime importance in biology, their use is hampered by the propensity of G4-prone DNA molecules, in particular G4-prone DNA molecules of long size, to adopt many different G4 topological conformations or other alternative foldings. By introducing a lipid modification at the end of the oligonucleotide, the inventors succeeded in obtaining long tetramolecular parallel G-quadruplexes (tp G4). The present invention thus concerns an oligonucleotide modified by substitution at the 5′ or the 3′ end by a lipid moiety, wherein said oligonucleotide comprises a nucleic acid sequence of at least 10 nucleotides, said nucleic acid sequence including a series of at least 4 consecutive guanine residues located at the 5′ or 3′ end of said sequence. A tetramolecular parallel G-quadruplex comprising 4 identical modified oligonucleotides as defined above, wherein each of the 4 consecutive guanine residues included at the 5′ or 3′ end of the nucleic acid sequence of each oligonucleotide respectively form G-quartets with the corresponding guanine residues of the other 3 oligonucleotides, said G-quartets being stabilized by π-π staking and Hoogsteen hydrogen bonding, is also contemplated.

The present invention concerns a material of formula (I): wherein: A is Na or Li or a mixture of Na and Li, 1 < x < 3 , 0 ≤ y ≤ 1 , 0 ≤ z ≤ 1 M is an electro-active transition element or a mixture of at least two electro-active transition elements, M′ is a non electro-active element or a mixture of at least two non electro-active elements, and the material of formula (I) presents a V/Z ratio varying from 212 Å 3 to 246 Å 3 .