Company patents

UNIVERSITY PUBLIC CORPORATION OSAKA

UNIVERSITY PUBLIC CORPORATION OSAKA's patent strategy shows a surprising shift away from its largest category, Material & Chemical Analysis, which has seen a significant decline of 85.7% so far in 2026, despite accounting for 33.7% of its portfolio. Concurrently, there's an emerging focus on Pharmaceutical Preparations and Therapeutic Activity (Pharma), both experiencing rapid growth of 300.0% in 2025, indicating a strategic pivot towards pharmaceutical innovation.

Patent Trend by Technology Area

Yearly patent publications since 2023

Product themes

Product-level themes inferred from filings since 2023, with category chips showing where each theme appears. Select a theme to filter the patents below.

83 US filings (since 2023) · 12 categories · 27 themes

Advanced Biomarker Detection Assays

Methods and compositions for identifying, quantifying, or characterizing specific biological molecules (e.g., nucleic acids, proteins, metabolites, antibodies) or microbial species, often for diagnostic, prognostic, or quality control applications.

Material & Chemical Analysis
Who else files here? →
15since 2023
-42.9%YoY
Solid-State Battery Manufacturing

Process and equipment for producing solid-state battery cells, including solid electrolyte synthesis (sulfide/oxide/polymer), thin-film deposition, lamination, sintering, dry-electrode fabrication, and stacking under controlled atmosphere.

Batteries & Fuel Cells
Who else files here? →
6since 2023
0.0%YoY
Microfluidic Lab-on-Chip Devices

Miniaturized devices that manipulate small volumes of fluids (nanoliters to picoliters) through microchannels to perform laboratory functions like mixing, separation, reaction, and detection on a single chip.

Laboratory ApparatusBioreactors / Cell Culture Apparatus
Who else files here? →
5since 2023
-33.3%YoY
Battery Electrode Coating & Slurry

Slurry compositions and coating processes for battery electrodes, including binder/active-material slurries, surface coating layers, and electrode-to-foil adhesion for cathode and anode.

Batteries & Fuel Cells
Who else files here? →
4since 2023
0.0%YoY
Antibody Engineering & Therapeutics

Design and modification of antibodies or antibody-derived fragments for targeted therapeutic intervention, including bispecific formats, Fc region modifications, and activatable constructs.

Peptides & ProteinsMaterial & Chemical AnalysisPharmaceutical PreparationsTherapeutic Activity (Pharma)
Who else files here? →
4since 2023
0.0%YoY
Automated Liquid Handling

Systems and components designed for precise, automated manipulation, transfer, and dispensing of liquid samples and reagents, often involving pipettes, robotic arms, and specialized sample containers.

Laboratory Apparatus
Who else files here? →
4since 2023
0.0%YoY
Specialized Culture Substrates & Scaffolds

Development of novel materials, surface patterns, or structural supports designed to enhance cell adhesion, proliferation, differentiation, or tissue formation, including hydrogels and patterned surfaces.

Bioreactors / Cell Culture Apparatus
Who else files here? →
3since 2023
new
Wearable Display Optics

Optical systems and components specifically designed for head-mounted displays, augmented reality (AR) glasses, and virtual reality (VR) headsets, focusing on image projection, waveguide integration, and display durability.

Optical Elements & Systems
Who else files here? →
3since 2023
new
3D Cell & Organoid Culture

Techniques and apparatus for cultivating cells in three-dimensional structures, including organoids, tissue models, and scaffolds, often involving microfluidics, specialized matrices, or mechanical stimulation to mimic in vivo conditions.

Bioreactors / Cell Culture Apparatus
Who else files here? →
3since 2023
n/a
Lithium Battery Anode Materials

Active anode materials and manufacturing techniques for rechargeable lithium-ion batteries, including silicon-carbon composites, graphite, lithium-metal anodes, and electrode coating processes that improve capacity, cycle life, and rate capability.

Batteries & Fuel Cells
Who else files here? →
2since 2023
new
Bioprocess Development for Proteins

Methods and systems for the efficient and scalable production, purification, and formulation of proteins and peptides, including fermentation, chromatography, and cell-based expression systems.

Peptides & Proteins
Who else files here? →
2since 2023
new
Immunomodulatory Protein Design

Design and engineering of proteins or peptides to directly modulate immune responses, including enhancing antigen presentation, suppressing inflammation, or activating specific immune cell types.

Peptides & Proteins
Who else files here? →
2since 2023
new
Nucleic Acid-Based Therapies

Therapeutic strategies employing nucleic acids (DNA, RNA, oligonucleotides) to modulate gene expression, deliver genetic material, or interfere with disease-causing pathways. Includes gene therapy using viral vectors.

Pharmaceutical PreparationsTherapeutic Activity (Pharma)
Who else files here? →
2since 2023
new
Immune Checkpoint Modulation

Therapeutic interventions that target immune checkpoint pathways to either enhance or suppress immune responses, often used in cancer immunotherapy or autoimmune diseases.

Therapeutic Activity (Pharma)
Who else files here? →
2since 2023
0.0%YoY
Advanced Cell & Gene Therapies

Development of therapeutic approaches involving the genetic modification of cells (e.g., T cells, stem cells, macrophages) or the use of viral/non-viral vectors to deliver genetic material for disease treatment.

Peptides & ProteinsPharmaceutical Preparations
Who else files here? →
2since 2023
n/a
Recombinant Protein & Peptide Therapeutics

Development and application of therapeutic proteins or peptides produced through recombinant DNA technology, including fusion proteins and modified growth factors.

Therapeutic Activity (Pharma)
Who else files here? →
2since 2023
n/a
Industrial Organic Synthesis

Methods and apparatus for the efficient and selective production of organic compounds, including amines, acids, and esters, often involving catalytic or continuous processes and purification steps.

Acyclic / Carbocyclic Compounds
Who else files here? →
2since 2023
n/a
Advanced Adsorbent & Separation Media

Development of materials with tailored porosity, surface chemistry, or structure, such as metal-organic frameworks (MOFs), zeolites, or superficially porous particles, for selective adsorption, ion exchange, or chromatographic separations.

Catalysts & Reactors
Who else files here? →
2since 2023
n/a
Emerging Contaminant Removal

Specific techniques and materials developed to remove persistent or difficult-to-treat pollutants from water, such as per- and polyfluoroalkyl substances (PFAS), micropollutants, or specific industrial chemicals.

Catalysts & Reactors
Who else files here? →
2since 2023
n/a
Weld Quality Monitoring & NDT

Systems and methods for assessing the quality and characteristics of welds or solder joints, often involving non-destructive testing (NDT) techniques, image processing, or real-time feedback for process control and defect detection.

Welding & Soldering
Who else files here? →
2since 2023
n/a
Cellular Immunotherapy

Therapeutic approaches involving the use of living cells, often genetically modified or ex vivo activated, to treat diseases, particularly cancer, by modulating immune responses or replacing damaged cells.

Therapeutic Activity (Pharma)
Who else files here? →
1since 2023
new
Metal Additive Manufacturing Processes

Techniques for building three-dimensional metal objects layer-by-layer using metal powders, including powder bed fusion, binder jetting, and directed energy deposition. This theme encompasses process mechanics, equipment design, and operational control for AM systems.

Electronic Design Automation (CAD/EDA)
Who else files here? →
1since 2023
new
Laser Material Processing

Techniques and systems utilizing laser beams for precise material modification, including cutting, cladding, ablation, and surface treatment, often for joining, shaping, or removing material.

Welding & Soldering
Who else files here? →
1since 2023
new
Targeted Small Molecule Therapeutics

Design and synthesis of acyclic or carbocyclic organic compounds that selectively modulate specific biological targets or pathways for the treatment of diseases.

Acyclic / Carbocyclic Compounds
Who else files here? →
1since 2023
n/a
Welding & Soldering Tool Design

Design and features of welding and soldering tools, fixtures, and accessories that enhance user safety, ergonomics, operational efficiency, and precise workpiece manipulation, including protective equipment and clamping mechanisms.

Welding & Soldering
Who else files here? →
1since 2023
n/a
Welding Process Control

Systems and methods for precisely controlling welding parameters such as power, speed, oscillation, and material feed to optimize weld quality, consistency, and efficiency, often involving automated or semi-automated processes.

Welding & Soldering
Who else files here? →
1since 2023
n/a
Integrated Display & Illumination

Systems that combine light sources, waveguides, and display elements into unified products for backlighting, automotive applications, general lighting, or color-corrected displays.

Optical Elements & Systems
Who else files here? →
1since 2023
n/a

Patents

Showing 1-10 of 132

Page 1 of 14
US 20260055207 A1APPLICATION
C07K16/32

HETERODIMERIC PROTEIN PRODUCTION METHOD, DIMERIC PROTEIN, MONOMERIC PROTEIN, AND TARGET RESPONSIVE HETERODIMERIC PROTEIN SCREENING METHOD

Filed:2023-05-26Pub:2026-02-26
Applicant:NATIONAL UNIVERSITY CORPORATION YAMAGATA UNIVERSITY

Provided is a method for producing a heterodimeric protein such as a bispecific antibody with which a heterodimeric protein composed of only domains having natural amino acid sequences can also be produced. A production method of the present invention is a method for producing a heterodimeric protein. The production method includes a production step of producing a heterodimeric protein by reacting a dimeric protein having a reaction tag with a modification protein for modifying the dimeric protein. The dimeric protein having a reaction tag includes a first monomeric protein and a second monomeric protein. The first monomeric protein includes a first reaction tag and a first dimer formation domain capable of forming a dimer in this order. The first reaction tag includes a binding tag and a first C intein. The second monomeric protein includes a second reaction tag and a second dimer formation domain capable of forming a dimer together with the first dimer formation domain in this order. The second reaction tag includes a binding partner capable of binding to the binding tag, and a second C intein. The modification protein includes a first modification protein and a second modification protein. The first modification protein includes a first N intein capable of reacting with the first C intein, and a first addition component to be added to the first monomeric protein. The second modification protein includes a second N intein capable of reacting with the second C intein, and a second addition component to be added to the second monomeric protein. The first addition component and the second addition component are different addition components. The first monomeric protein and the second monomeric protein form a dimer. In the production step, the first N intein of the first modification protein reacts with the first C intein of the first monomeric protein, and then the first addition component of the first modification protein is linked to the first monomeric protein, and the second N intein of the second modification protein reacts with the second C intein of the second monomeric protein, and then the second addition component of the second modification protein is linked to the second monomeric protein.