VERO Biotech Inc.

A method for delivering nitric oxide therapy to a subject can include administering a composition including a nitric-oxide releasing agent and silica to the subject and releasing a therapeutic amount of nitric oxide from the composition.

Disclosed herein is a device comprising: a media configured to convert nitrogen dioxide into nitric oxide, wherein the media comprises: (a) a support material; and (b) an antioxidant material, wherein at least 15 wt % of the antioxidant material is present in a solid form.

A system for delivering a therapeutic amount of nitric oxide can include a reservoir including a restrictor with a length of at least 0.5 inches and at most 2 inches covered by a metal sheath, a gas supply, and a delivery conduit. A delivery conduit can include at least one cartridge and a patient interface. The at least one cartridge can include a surface-active material and a reducing agent.

Disclosed herein is a system and method comprising an apparatus for delivering a therapeutic amount of nitric oxide to a subject, the apparatus comprising at least one air inlet; a first receptacle configured to host a first source of nitric oxide; a second receptacle configured to host a second source of nitric oxide; a control unit configured to communicate with the first receptacle and the second receptacle and to selectively couple the at least one air inlet to at least one of the first receptacle or the second receptacle to deliver the nitric oxide from the first or the second source; a first outlet coupled to the first receptacle to deliver nitric oxide; and a second outlet coupled to the second receptacle to deliver nitric oxide. The first source can be provided to a ventilator and the second source can be provided to an ECMO device.

Start-up protocols for a device and method for administering NO is described.

A device and method for calibrating a NO delivery device using NO and NO 2 measurements, without using a known standard.

A device and method for calibrating a NO delivery device using NO and NO 2 measurements, without using a known standard.

Disclosed herein is a single-use container for forming a therapeutic amount of nitric oxide to be delivered by an apparatus to a subject, wherein the single-use container comprises: a housing defined by a proximal edge and a distal edge and comprising: a first chamber comprising N 2 O 4 , wherein the first chamber is sealed; a second chamber comprising an antioxidant material; and wherein the first chamber and the second chamber are positioned relative to each other such that when the single-use container is inserted into the apparatus and is activated, the first chamber is unsealed to allow the liquid N 2 O 4 to be in fluid communication with the antioxidant material in the second chamber to produce nitric oxide.

Dinitrogen tetroxide (N 2 O 4 ) is synthesized in an apparatus by the reaction of concentrated nitric acid with copper. Oxygen is applied as a carrier gas to convert NO to NO 2 , and water vapor is removed with a tube dryer. A molecular sieve is applied to reduce and remove impurities.

Disclosed herein is a device comprising: a media configured to convert nitrogen dioxide into nitric oxide, wherein the media comprises: (a) a support material having a surface area of 350 to 5000 m 2 /g; and (b) an antioxidant material.