West Pharmaceutical Services, Inc.

An injection device ( 10 ) includes a lower housing ( 18 ), a sleeve ( 32 ) supported by the lower housing, and a syringe spring ( 34 ) received within the sleeve. The spring supports a syringe ( 12 ). A needle guard ( 26 ) is proximally slidable relative to the lower housing from a first position, concealing the syringe needle ( 12 b ), to a second position. A needle guard spring ( 27 ) biases the needle guard distally relative to the lower housing. An upper housing ( 16 ) is distally slidable relative to the lower housing from a pre-use position to a dispensed position. Movement of the needle guard from the first position to the second position extends the distal tip of the needle distally beyond the needle guard by a first distance. Subsequent distal movement of the upper housing relative to the lower housing from the pre-use position toward the dispensed position advances the distal tip of the needle distally further beyond the needle guard by a second distance.

An adapter for connecting one or more storage containers with a syringe is described. The adapter includes a first port that provide a connection with a first container volume, a second port that provides a connection with a second container volume, a third port that provides a connection to a syringe. The adapter further includes a mixing channel extending from a first end in fluid communication with the third port to a second end. The mixing channel includes a tortuous path along at least a portion of its length. The mixing channel enables two constituents of a pharmaceutical complex to be mixed through the mixing channel to form the pharmaceutical complex. Also disclosed is a system including such an adapter, a method of mixing two constituents of a pharmaceutical complex via such an adapter and a method of manufacturing such an adapter.

A system for injecting medicament into a target region includes a syringe with a barrel to contain the medicament, a movable plunger within the barrel, and a needle in fluid communication with the barrel that has a tip. The system includes a sensor configured to sense backpressure exerted on the plunger. A controller is then used to determine satisfaction of a needle advancement criteria based on the sensed backpressure. The needle advancement criteria being associated with the tip of the needle extending through target tissue into the target region.

A packaging system for sealing a medicine container having a filling opening with a stopper includes a container tray having a container cell for receiving and stabilizing the medicine container, a stopper tray with a stopper carrier, and a cover securable to the stopper tray to secure the stoppers to the stopper tray. The stopper carrier forms a body with a proximal opening, an interior space, a distal inner surface, and at least one stopper-locating surface.

Systems and methods for medical device usage management are disclosed. In an example method, an indication that an injection was administered to a patient by a medical device can be received. The indication may be received wirelessly from the medical device. One or more measurements of a physiological characteristic of the patient captured by a sensor associated with the patient can also be received. The indication that the injection was administered to the patient by the injector and the one or more measurements of the physiological characteristic of the patient can then be transmitted.

A method for manufacturing a syringe is described. The syringe includes a barrel having an open proximal end, a piston shaft having proximal and distal ends, and a piston having a longitudinal axis and opposing proximal and distal axial ends. Initially, a partially formed piston body is molded. The piston is then completely molded. The distal end of the piston shaft is engaged with the proximal axial end of the piston. The piston engaged with the piston shaft is received in the open proximal end of the barrel.

A packaging system for sealing a medicine container having a filling opening with a stopper includes a container tray having a container cell for receiving and stabilizing the medicine container. A shuttle has an exterior surface and an interior surface. The interior surface is configured for releasably securing the stopper. The shuttle is configured to release the stopper into the fill opening upon application of a releasing force to the exterior surface of the shuttle. A shuttle tray has a shuttle cell. The shuttle cell forms a body with a proximal opening, an interior space, a bottom inner surface opposite the proximal opening, and a side inner surface. The shuttle cell releasably secures the shuttle.

A syringe safety system may include a sleeve. The sleeve may include a guide track formed in the sleeve. The guide track may have a guide pin retention portion, a travel portion, and a lockout portion. The syringe safety system may include a collar having a guide from an exterior surface of the collar. A spring may extend between and be coupled to the collar and the sleeve. A cap may engage the sleeve. The cap may be configured to retain the guide pin in the guide pin retention portion of the guide track. When the cap is removed, the spring advances the guide pin into the travel portion of the guide track.

Layered polymer materials include a first layer including a first cyclic olefin polymer or a first cyclic olefin copolymer, a third layer including a second cyclic olefin polymer or a second cyclic olefin copolymer, and a second layer including an amphiphilic polymer having a hydrophilic component with a Hansen Solubility Parameter distance of 8 MPa 1/2 or greater from oxygen gas, while at the same time having a hydrophobic component with a Hansen Solubility Parameter distance of 8 MPa 1/2 or less from COC or COP. The second layer can be in contact with and be between the first layer and the third layer. The layered polymer material can be used to construct the body of a vial or a syringe. Methods of making the layered polymer material and kits containing the layered polymer material or containers having a body constructed from the layered polymer material are also described.

A medical device component is provided. The medical device component may include a body having a first surface being at least partially formed from a markable material having a first color, the markable material having a characteristic that an area exposed to laser irradiation of a predetermined wavelength of ultraviolet light changes to a second color different from the first color; a film covering at least a portion of the first surface of the body, the film having a transmittance at the predetermined wavelength of ultraviolet light of at least 5%; and a visible mark on the markable material at the first surface of the body covered by the film. The visible mark may include one or more areas of the markable material at the first surface having the second color. Methods of manufacturing the medical device component are also provided.