WESTLAKE UNIVERSITY

A tiling light sheet microscope and imaging method of a sample. The imaging method includes: generating a first laser beam of a first wavelength range and generating a second laser beam of a second wavelength range; performing a first optical modulation on the first laser beam and performing a second optical modulation on the second laser beam; and then combining the first laser beam and the second laser beam. The combined laser beams are directed onto an illumination path, to generate, by scanning the laser beams, a first excitation light sheet and a second excitation light sheet corresponding to the first wavelength range and the second wavelength range, respectively. The two types of excitation light sheets are combined in a propagation direction of excitation light so as to illuminate the sample. The fluorescences emitted by the sample are collected. In this way, for various biological tissues, at least dual-color simultaneous imaging can be performed, to keep same spatial resolution without increasing image acquisition time.

The present disclosure provides a method and an apparatus for train re-scheduling based on a diffusion model and reinforcement learning. A method for train re-scheduling includes: obtaining time series data indicating states, including a train operation state, a resource allocation state and an external environment state, at respective time points during a train operation process; providing the obtained time series data to a trained neural network model to generate a scheduling strategy for train re-scheduling, the scheduling strategy including an action to be performed by a train scheduling system; and instructing the train scheduling system to perform the generated scheduling strategy, where the neural network model includes a diffusion model and a reinforcement learning model.

A duchenne muscular dystrophy-related exonic splicing enhancer, sgRNA and gene editing tool can be applied in the preparation of drugs for treating duchenne muscular dystrophy. The gene editing tool designed on the basis of cytosine deaminase AID mutants and Cas9 mutants can perform site-specific modification on a mammalian genome by using an adeno-associated virus (AAV) as a vector. By optimizing an encoding nucleic acid sequence and an element composition structure of the editing tool, site-specific targeted modification of mammalian genetic material DNA can be efficiently achieved; and by performing targeted genetic manipulation on the nucleic acid sequence carrying disease mutations, a pathogenic mutation cannot be retained in a mature protein amino acid sequence or the pathogenic mutation cannot perform its function, so that the purpose of treating various gene mutation type genetic rare diseases is achieved, and the advantages of high efficiency, safety and stability are achieved.

The disclosed invention is generally in the field of synthetic small molecules and their use as drug, in particular in the treatment of cancer. Also provided is a method of inhibiting cancer stem cells. Also provided is a method for treatment of cancers and other diseases by affecting mitochondrial functions. Also provided is a method of making and using of the compounds.

The present invention refers to a method for treating Notch signaling-dependent disease in the subject with a FBXO42 specific inhibitor. The Notch signaling-dependent disease is selected from leukemia. Also provided is a method for screening a drug treating Notch signaling-dependent disease using FBXO42 as a target.

An optical pumping-based multimodal fusion detection apparatus is provided, relating to the field of brain-computer interfaces. The system includes a laser generation module, laser path control module, atomic vapor cell, photodetection module, ultrasonic detection module, and data processing module. The photodetection module, ultrasonic detection module, and data processing module function as a detection module. The detection module collects the laser intensity and polarization variation signals of the first laser after passing through the atomic vapor cell to output local magnetic field variations in the brain caused by neural discharges. It also collects ultrasonic signals corresponding to an interaction of the second pulsed laser with the measured part to output the subject's blood oxygen signal.

Origami-based contact members, devices and systems used for active mechanical haptics. The origami-based contact member includes a top plate, a bottom plate, and at least one piece of a curved origami-based metamaterial interposed therebetween, with its top end fixed to the top plate and its bottom end fixed to the bottom plate, the top plate is exposed to be contacted by a user's body site. The metamaterial includes a panel having a single curved crease extending in its longitudinal direction, which divides the panel into two facets. The panel is foldable along the single curved crease to form a folding angle between the two facets. The folding angle is adjustable by rotating the bottom plate to achieve a variable stiffness when loaded in a vertical axis between the top and bottom plates, covering positive stiffness to negative stiffness, to be perceived by the user's body site via contact with the top plate.

A mask, a lithographing apparatus, and a method for manufacturing a mask, wherein the mask includes: an electrolytic reaction layer ( 110 ) in which metal element is configured to be in a deposited-metal state or a dissolved-ion state; a first control circuit layer ( 120 ) provided on a first side of the electrolytic reaction layer ( 110 ) and including a plurality of first control electrodes ( 121 ); and a second control circuit layer ( 130 ) provided on a second side of the electrolytic reaction layer ( 110 ) that is opposite to the first side and including a plurality of second control electrodes ( 131 ), wherein a light-transmitting state of a pixel region in the mask is configured to be decided by a control voltage between at least a part of the first control electrode ( 121 ) and at least a part of the second control electrode ( 131 ) contained in the pixel region, and the control voltage controls the light-transmitting state of the pixel region by controlling a deposition amount of metal in the electrolytic reaction layer ( 110 ).

Embodiments of the present disclosure provide an underwater vehicle, comprising a frame and a driving device; wherein a wing fixing support rod, a wing rotating support rod and a wing tip support rod are provided on the driving device, a first end of the wing fixing support rod and a first end of the wing rotating support rod are movably connected to the driving device, a second end of the wing rotating support rod is movably connected to the wing tip support rod, and at least one main wing rib is provided on the wing fixing support rod and the wing rotating support rod, and at least one wing tip wing rib is sleeved on the wing tip support rod. According to the embodiments of the present disclosure, by providing a plurality of energy storage motor devices, the wing of the underwater vehicle can achieve different individual motions, and a combination of a plurality of individual motions can constitute a complex spatial motion, so that the navigation modes of the underwater vehicle are more diversified, and the biomimetic effect is better.

The present disclosure relates to a detection method and apparatus, an object monitoring system, a computing device, and a storage medium. The detection method includes acquiring an image containing a 2D code for an object, and inputting the image into a pre-trained multi-target detection model configured to detect multiple classes of detection targets including the 2D code. The method further includes at least one of: based on a detection box of the 2D code in the image, cropping out an image region of the determined detection box of the 2D code from the image, and recognizing the 2D code from the cropped image region; or, based on an actual size of the 2D code, a size of the 2D code in the image, and a position of the 2D code in the image, determining an actual position of the 2D code relative to an imaging device.