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Chemical Synthesis of Drug Intermediates
Processes and methodologies for the efficient and scalable preparation of complex heterocyclic compounds and their precursors, including specific reaction conditions, purification techniques, and intermediate compounds.
4,526 US filings from 1,702 companies since 2023 · 2023: 1,397 · 2024: 1,452 · 2025: 1,204 · 2026 YTD: 473
Heterocyclic Compounds (Pharma)
Top companies
Ranked by filings in this theme since 2023. 2026 is partial.
| # | Company | Since 2023 | 2023 | 2024 | 2025 | 2026 YTD | YoY |
|---|---|---|---|---|---|---|---|
| 1 | KING FAISAL UNIVERSITY | 247 | 4 | 226 | 17 | · | -92.5% |
| 2 | BASF SE | 121 | 40 | 37 | 30 | 14 | -18.9% |
| 3 | BAYER AKTIENGESELLSCHAFT | 62 | 12 | 20 | 20 | 10 | 0.0% |
| 4 | Hoffmann-La Roche Inc. | 51 | 6 | 23 | 16 | 6 | -30.4% |
| 5 | INTRA-CELLULAR THERAPIES, INC. | 46 | 14 | 9 | 21 | 2 | +133.3% |
| 6 | AMGEN INC. | 45 | 13 | 5 | 23 | 4 | +360.0% |
| 7 | AbbVie Inc. | 39 | 23 | 14 | 2 | · | -85.7% |
| 8 | Enveric Biosciences Canada Inc. | 36 | 9 | 9 | 13 | 5 | +44.4% |
| 9 | Evonik Operations GmbH | 33 | 13 | 9 | 7 | 4 | -22.2% |
| 10 | ENTEGRIS, INC. | 30 | 9 | 8 | 8 | 5 | 0.0% |
| 11 | SYNGENTA CROP PROTECTION AG | 29 | 10 | 6 | 8 | 5 | +33.3% |
| 12 | Compass Pathfinder Limited | 27 | 8 | 6 | 9 | 4 | +50.0% |
| 13 | FIRMENICH SA | 26 | 5 | 8 | 9 | 4 | +12.5% |
| 14 | FUDAN UNIVERSITY | 26 | 12 | 7 | 3 | 4 | -57.1% |
| 15 | DSM IP ASSETS B.V. | 25 | 11 | 9 | 4 | 1 | -55.6% |
| 16 | FMC Corporation | 25 | 11 | 3 | 10 | 1 | +233.3% |
| 17 | SHIN-ETSU CHEMICAL CO., LTD. | 25 | 11 | 7 | 5 | 2 | -28.6% |
| 18 | ADAMA MAKHTESHIM LTD. | 21 | 6 | 4 | 8 | 3 | +100.0% |
| 19 | HANWHA SOLUTIONS CORPORATION | 21 | 9 | 6 | 4 | 2 | -33.3% |
| 20 | SOOCHOW UNIVERSITY | 21 | 8 | 9 | 4 | · | -55.6% |
| 21 | ELI LILLY AND COMPANY | 20 | 5 | 4 | 10 | 1 | +150.0% |
| 22 | Genentech, Inc. | 20 | 5 | 9 | 6 | · | -33.3% |
| 23 | LG Chem, Ltd. | 20 | 4 | 14 | 1 | 1 | -92.9% |
| 24 | PURDUE RESEARCH FOUNDATION | 20 | 7 | 4 | 6 | 3 | +50.0% |
| 25 | API CORPORATION | 19 | 4 | 11 | 4 | · | -63.6% |