Bard Peripheral Vascular, Inc.

Embodiments of the invention relate to embolic compositions having immunomodulating components therein and methods for using the embolic compositions to treat cancer. The embolic compositions include a hydrogel embolic with the immunomodulator(s) therein.

A guidewire loading system includes a catheter having a catheter body having an internal lumen and a snare. The snare is positioned at least partially within the internal lumen of the catheter body. The snare includes a snare body and a first capture flare extending from a first end of the snare body and configured to receive the guidewire. The catheter body compresses the first capture flare to form a friction grip around the guidewire when the snare, including the first capture flare, and guidewire are pulled at least partially through the internal lumen of the catheter body.

Compositions and methods related to hydrogel tissue sealants are generally described. In certain embodiments, a hydrogel forming composition is provided in dry form (e.g., as one or more powder mixtures) and comprises at least an electrophilic polymer crosslinking agent and a nucleophilic polymer such as a protein that is capable of crosslinking with the crosslinking agent. One or more solvents able to dissolve the crosslinking agent and the protein can be provided and used to dissolve the hydrogel forming composition to facilitate crosslinking.

A thrombectomy device for removing a material from a subject includes a catheter, a diaphragm, and a vacuum. The catheter includes an outer body defining a lumen extending therethrough. The diaphragm is coupled to the catheter and is moveable between an open diaphragm configuration and a closed diaphragm configuration. The diaphragm allows movement of the material through the lumen when in the open diaphragm configuration and prevents movement of the material through the lumen when in the closed diaphragm configuration. The vacuum is in communication with the lumen and is operable to exert a vacuum pressure on the diaphragm. The vacuum pressure is operable to move the diaphragm from the open diaphragm configuration to the closed diaphragm configuration.

An example thrombectomy device includes a catheter having a proximal region and a distal region. The thrombectomy device also includes a plurality of atraumatic fingers extending from the proximal region. The atraumatic fingers collectively define an outer periphery of the atraumatic fingers. The thrombectomy device also includes a coring ring attached to the atraumatic fingers such that at least a portion of the coring ring is disposed within the outer periphery of the atraumatic finger. The thrombectomy device also includes a capture bag extending from the distal region of the catheter. The thrombectomy device is configured to switch between a collapsed state and deployed state, wherein the atraumatic fingers, the coring ring, and the capture bag are positioned adjacent to the catheter in the collapsed state and are at least partially spaced from the catheter in the deployed state.

A radiotherapy delivery device includes a body having a first end and a second end and a catheter having a lumen extending between a proximal end and a distal end. The proximal end of the catheter is coupled to the second end of the body and the distal end of the catheter includes a cutting tip that penetrates a target site. A sealed pouch containing radioactive particles is positioned within the lumen of the catheter, and a puncture shaft is positioned coaxially within the body. The puncture shaft advances in a longitudinal direction into and through the sealed pouch to release the radioactive particles. A syringe is fluidly coupled to the lumen of the catheter, and the radioactive particles released by the sealed pouch are deposited into the target site when fluid is supplied from the syringe and into the lumen of the catheter.

Radiation sealing assemblies and methods of use of a radiation containment component for sealing a microcatheter used to deliver a mixed particulate from a particulate delivery device for disposal, which may include a proximal end and a distal end disposed opposite the proximal end. The proximal end is configured to connect to and cover a distal portion of a delivery line connector of the particulate delivery device, the delivery line connector configured to receive the mixed particulate from the particulate delivery device. The distal end is configured to be disposed over and contain the microcatheter connected to the delivery line connector after use, and the distal end is configured to seal together to contain the microcatheter prior to disposal.

A device for deploying markers includes a deployment catheter, a first push rod, and a second push rod. The deployment catheter includes an elongate body and a cutting tip at a distal end of the elongate body. The deployment catheter defining a first lumen separate from a second lumen. The first lumen having a first proximal opening and a distal opening at the cutting tip. A deployment portion positioned therebetween. The second lumen having a deployment opening and a second proximal opening. The second lumen shaped and sized to hold a plurality of markers. The second push rod independently pushes each of the plurality of markers from the second lumen into the first lumen into a deployed position within the deployment portion. The first push rod pushes the one of the plurality of markers from the deployed position out of the distal opening at the cutting tip.

A vial assembly includes a vial and a needle with at least one port. The vial includes a particulate material, a septum, a neck region including a first width, and a particulate region including a second width greater than the first width. The vial assembly is configured to move to a locked position. The needle may be configured to puncture the septum with the at least one port configured to be in the neck region when in the locked position. The at least one port may be configured to inject a fluid into the vial assembly to mix with the particulate material upon actuation of a vial engagement mechanism in a first direction and to receive a resulting mixed fluid from the vial assembly upon actuation of the vial engagement mechanism in a second direction opposite the first direction.