Radiometer Medical ApS

Disclosed is a method and device/apparatus for determination of the contribution from lysed cells to measurement values of an analyte present in the extracellular compartment. The method employs multiple tandem measurements of analyte and an intracellular marker from samples where different numbers of cells are lysed so as to establish the relationship between the measured value of the intracellular marker and the analyte.

The present disclosure relates to a sensor device, comprising: a measurement chamber having at least a first wall, the measurement chamber including a plurality of analyte sensors; wherein the measurement chamber allows a fluid to be analyzed to interact with each of the plurality of analyte sensors when the fluid is accommodated within the measurement chamber; the measurement chamber having an inlet configured to receive the fluid to be analyzed and an outlet configured to allow the fluid to exit the measurement chamber after having interacted with the plurality of analyte sensors; the measurement chamber defining a sample volume for accommodating the fluid to be analyzed, the sample volume extending at least between the inlet and the outlet; a heating element configured to heat the fluid accommodated within the measurement chamber.

A waste pouch for biological waste from a blood analyser device is provided, as well as a cassette comprising said waste pouch, and a blood analyser device comprising said pouch or said cassette. The pouch comprises an envelope, a vent in the upper surface of the envelope for outlet of gas, and an opening for receiving liquid and gaseous waste. The pouch comprises a superabsorbent polymer contained in the envelope, said superabsorbent polymer being in the form of beads.

The disclosure relates to a method of detecting a clot in a measurement chamber of a liquid sample analyzer, wherein the liquid sample analyzer comprises at least two analyte sensors, a first analyte sensor, for measuring a first analyte in a liquid sample, and one or more second analyte sensors, for measuring one or more second analytes in the liquid sample in the measurement chamber, the method comprising the steps of, (a) at least partly filling the measurement chamber with a known solution having a composition comprising the first analyte at a pre-determined level, and the second one or more analytes at pre-determined levels, (b) obtaining a first sequence of measurement results by the first analyte sensor, and simultaneously obtaining a second sequence of measurement results by the second, one or more analyte sensors, (c) determining a change of the first sequence of measurement results, (d) determining a change of the second or more sequence of measurement results, and (e) comparing the change of the first sequence of measurement results with the second sequence of measurement results.

A blood analyser and related methods, in particular a method of analysing a blood sample is disclosed. The blood analyser comprises a memory, an interface, and one or more processors. The blood analyser is configured to obtain image data of a prepared blood sample; select a first image associated with a first image plane of the prepared blood sample from the image data; characterize the first image, wherein the characterization of the first image comprises to determine a first set of cell regions belonging to the first image plane; select a first distal image associated with a first distal image plane on a distal side of the first image plane, and determine a first distal set of distal cell regions associated with the first set of cell regions; and determine a first cell parameter for each cell region of the first set of cell regions based on the first distal set of distal cell regions.

A system (10) for determining a refractive index of a sample fluid or a concentration of a component in the sample fluid comprises a transparent sensing element (12) with a plurality of pores (122) for receiving a fluid. The pores reflect or scatter radiation emitted by a radiation emitter (14) of the system differently depending on the refractive index of the fluid. The system comprises one or more detectors (16) for detecting the reflected and/or scattered radiation. The refractive index of the sample fluid is determined based on the detected scattered and/or reflected radiation when the sample fluid is fed into the pores, the corresponding detected scattered and/or reflected radiation when first and second calibration fluids having predetermined refractive indexes and predetermined absorptions at at least two wavelengths are fed into the pores, said predetermined refractive indexes and said predetermined absorptions. Alternatively, a concentration of a component in the sample fluid absorbing at a given wavelength may be determined based on the detected scattered and/or reflected radiation, a predetermined refractive index of the sample fluid, a predetermined refractive index and a predetermined absorption at said wavelength of a calibration fluid, and the detected scattered and/or reflected radiation when the calibration fluid is fed into the pores.

The present invention relates a porous membrane sensor element for the detection of an analyte in a complex fluid sample. The porous membrane sensor element comprises: a porous membrane sensor housing penetrated by a flow channel defining an axial direction, the flow channel comprising a sample space; a porous membrane with a front side defining a sensor surface for contacting the fluid sample, the sensor surface facing towards the sample space, the porous membrane comprising pores extending from respective openings at the sensor surface into the porous membrane, wherein the pores are configured with regard to the analyte for diffusive fluid communication with the sample space; and an optical subassembly comprising a light guide core, the light guide core comprising an input branch, an output branch, and a coupling interface arranged to contact a backside of the porous membrane opposite to the front side and facing away from the sample space; wherein the input and output branches are directed towards the coupling interface. The input branch and the output branch are arranged in a common light guide plane arranged perpendicular to the sensor surface. According to a further aspect, a sensor assembly comprises a porous membrane sensor element integrated within a sample chamber thereof.

A syringe for obtaining a target volume of blood is presented. The syringe ( 1 ) comprises a barrel ( 2 ), wherein a plunger ( 4 ) is arranged within the barrel ( 2 ) to be displaceable along a displacement direction (X). Furthermore the barrel ( 2 ) and the plunger ( 4 ) together provide for a first stop ( 20 ) and second stop ( 22 ), wherein the first stop ( 20 ) is configured for positioning a filter ( 100 ) at a predetermined location along the displacement direction (X) thereby defining a target volume of blood and a buffer volume. Moreover, the second stop ( 22 ) is configured to stop the plunger ( 4 ) from expelling more than the buffer volume from the syringe ( 1 ) for obtaining the target volume of blood when the plunger ( 4 ) is pushed towards the distal end ( 30 ) of the syringe ( 1 ) along the displacement direction (X). In addition, the syringe ( 1 ) facilitates that the syringe ( 1 ) fills itself with the target volume of blood by a self-filling procedure using blood that is under pressure, like arterial blood, and using the filter ( 100 ) located in the plunger ( 4 ).

An apparatus that determines time response values of at least one analyte in a liquid includes a translucent element having dead end pores extending into the translucent element from respective openings in the translucent element. A cross-sectional dimension of the openings is dimensioned to prevent larger particles or debris from entering the pores while allowing the analyte(s) in the liquid to enter the pores via diffusion. One or more light sources illuminates the pores. A light detector receives light emerging from the pores in response to illumination by the one or more light sources. The light detector generates one or more signals based on the received light. Each signal is temporally resolved and representative of at least a part of the received light. The apparatus further includes a data processing device having a processor that determines one or more time response values based on the one or more signals.

A blood gas analyzer for performing a measurement of analytes in a blood sample, such as a whole blood sample, aspirated into the blood gas analyzer from a handheld blood sample container includes a controller, and a sensor system for detecting a presence, a position and/or an orientation of the handheld blood sample container relative to an inlet structure. An aspiration system is provided for aspirating the blood sample from the handheld blood sample container, the aspiration system connectable to the handheld blood sample container. A user interface system is provided for outputting instructions to a user of the blood gas analyzer, the instructions being selected among pre-stored sets of instructions. The controller selects one of the at least two pre-stored sets of instructions based on an assessment of a signal retrieved from the sensor system.