Radiometer Medical ApS

Disclosed is a method and device/apparatus for determination of the contribution from lysed cells to measurement values of an analyte present in the extracellular compartment. The method employs multiple tandem measurements of analyte and an intracellular marker from samples where different numbers of cells are lysed so as to establish the relationship between the measured value of the intracellular marker and the analyte.

A blood gas analyzer for performing a measurement of analytes in a blood sample, such as a whole blood sample, aspirated into the blood gas analyzer from a handheld blood sample container includes a controller, and a sensor system for detecting a presence, a position and/or an orientation of the handheld blood sample container relative to an inlet structure. An aspiration system is provided for aspirating the blood sample from the handheld blood sample container, the aspiration system connectable to the handheld blood sample container. A user interface system is provided for outputting instructions to a user of the blood gas analyzer, the instructions being selected among pre-stored sets of instructions. The controller selects one of the at least two pre-stored sets of instructions based on an assessment of a signal retrieved from the sensor system.

The invention relates to a patient sample analysis system. The system comprises: at least one medical analysis device adapted to receive a sample, perform a measurement on the sample, and produce a measurement result based on the measurement, wherein the measurement result has a unique identifier; and a medical device management apparatus comprising an input interface adapted to collect the measurement result from the at least one medical analysis device, an output interface adapted to output sample analysis data based on the measurement result towards a point of delivery, and at least one processing module arranged in a data path extending from an upstream end at the input interface to a downstream end at the output interface. The patient sample analysis system further comprises: one or more check points arranged in the data path, wherein each check point is configured to identify the result by the unique identifier and to add a corresponding result status entry in relation to the unique identifier to a check point record, when the result is passed through said check point; and an error handler operable to inspect the check point record, detect the occurrence of an error based on that inspection, determine an error location of the error on the data path, and develop an error correction based on the error location. In a further aspect, a corresponding method for handling medical sample analysis is disclosed.

Disclosed herein are embodiments of a method for calibrating a group of analyzer units, each analyzer unit of the group of analyzer units configured for determining an amount of an analyte in plasma of a whole-blood sample. The method comprises: providing a plurality of calibration whole-blood samples, the plurality of calibration whole-blood samples including calibration whole-blood samples having respective hematocrit levels, for each calibration whole-blood sample of the plurality of calibration whole-blood samples: measuring a hematocrit measurement value indicative of the hematocrit level of said calibration whole-blood sample, measuring a whole-blood measurement value indicative of an amount of the analyte in the calibration whole-blood sample using at least one calibration analyzer unit of said group of analyzer units, measuring a plasma measurement value indicative of an amount of the analyte in plasma of said calibration whole-blood sample, and computing a ratio between the whole-blood measurement value and the plasma measurement value; generating a nonlinear functional relationship between the computed ratios and the corresponding hematocrit measurement values by curve fitting of a nonlinear function parametrized by one or more calibration parameters, the curve fitting resulting in respective parameter values of the one or more calibration parameters; storing a representation of the fitted nonlinear function in each analyzer unit of the group of analyzer units to allow each analyzer unit of the group of analyzer units to compute a hematocrit correction factor.

The present invention relates to methods for determining a blood gas parameter and/or a basic metabolic panel parameter in a blood sample comprising combining the blood sample with an anti-coagulant and an anti-platelet agent, and determining said blood gas parameter and/or parameter in the sample. In some aspects, the invention relates to determining said parameters in samples that have been subjected to pre-analytical stress.

A biological fluid analyser is disclosed. The biological fluid analyser is configured to obtain image data of one or more image planes of an image stack in a prepared biological fluid sample. The image data comprises first image data associated with a first image plane. To obtain the first image data comprises to obtain first primary image data of the first image plane. The first primary image data is associated with a first incident light setting. The first incident light setting has a first angular light distribution. To obtain the first image data comprises to obtain first secondary image data of the first image plane. The first secondary image data is associated with a second incident light setting. The second incident light setting has a second angular light distribution. The biological fluid analyser is configured to classify, based on the first primary image data and the first secondary image data, a cell in the prepared biological fluid sample for provision of a cell parameter associated with the cell.

A computer-implemented method performed by a central system for establishing control ranges for a plurality of remote medical analyzer devices is disclosed. The method comprises obtaining a plurality of measurement results associated with a plurality of quality control (QC) measurements performed by a plurality of medical analyzer devices on a set of predefined QC samples. Each QC sample is associated with a predefined target range and wherein each medical analyzer device is associated with a peer group of medical analyzer devices. The method further comprises determining, for each peer group out of a plurality of peer groups, a peer control range for each predefined QC sample by processing the plurality of measurement results of the peer group in view of the associated target range. Furthermore, the method comprises determining, for each medical analyzer device, a control range for each predefined QC sample based on the determined peer control range of the associated peer group. The method further comprises transmitting, to a device for managing at least one medical analyzer device, data indicative of the determined control ranges for the set of predefined QC samples for the at least one medical analyzer device.

A computer-implemented method for supporting maintenance of an apparatus for analyzing biological samples, the apparatus including at least one hardware component subject to maintenance, the method comprising: receiving a plurality of measurement results, each measurement result being derived from a measurement performed by the apparatus for analyzing biological samples on a biological sample or on a quality control sample, the plurality of measurement results including measurement results obtained at different times; computing a time series of a performance parameter from the plurality of measurement results, the performance parameter being indicative of an operational state of said at least one hardware component, the time series representing a period of time having a start time and an end time, the end time being no later than a current time; extrapolating, using a predetermined extrapolation model, the computed time series to obtain an extrapolated time series of the performance parameter, the extrapolated time series including one or more estimated values of the performance parameter at one or more future times; comparing the one or more estimated values of the performance parameter with a predetermined condition indicative of a risk of component failure of said component to determine an estimated future time at which said predetermined condition is fulfilled; determining an estimated failure time from the estimated future time

A blood analyzer for analyzing multiple blood parameters is disclosed. The blood analyzer comprises an inlet module configured to receive an initial blood sample, a blood gas sensor device in fluid communication with the inlet module, the blood gas sensor device configured to receive a first blood sample of the initial blood sample and conduct a blood gas analysis on the first blood sample to determine a blood gas analysis parameter, a blood count sensor device in fluid communication with the inlet module, the blood count sensor device configured to receive a second blood sample of the initial blood sample and determine a blood count parameter, and an output configured to provide the blood gas analysis parameter and the blood count parameter.

There is presented a method of measuring one or more potential differences being indicative of one or more concentrations of one or more analyte ions in a sample, such as being a liquid whole blood sample, said method comprising, measuring with a reference ion measurement setup a parameter indicative of a concentration of a reference ion in the sample wherein the reference ion measurement setup is different from an electroanalytical measurement setup, measuring with an analyte ion measurement setup one or more potential differences directly or indirectly between each of one or more, optionally solid-state, working electrodes with each of said, optionally solid-state, working electrodes comprising an ion-selective electrode which is selective for an analyte ion, and an, optionally solid state, reference electrode which is selective for the reference ion wherein the analyte ion measurement setup is an electroanalytical setup. There is additionally presented an apparatus and use of said apparatus.