Technische Universität Darmstadt

The present invention relates to macrocyclic FKBP51-binding compounds having improved characteristics, as well as solvates, hydrates and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said compounds have been identified as especially potent ligands of FK506 binding proteins (FKBPs also called MIPs in bacteria), especially human FKBP51 and are useful for treatment of diseases such as psychiatric, metabolic and neurological disorders as well as pain and cancers. Said substituted derivatives may further be used as agents for inducing protein-protein interactions (PPIs) acting as molecular glues (FIG. 10 ).

Novel environmentally friendly, wet strength improved fibrous non-woven fabrics, optionally paper, impregnated with a mixture including a silicon component, further including water and/or an alcohol and/or a surfactant and a catalyst. Also encompassed are methods for production and uses of such wet strength improved fibrous non-woven fabrics.

In a method for coating a base body, a first target and a second target are arranged in a vacuum chamber. A base body to be coated is arranged in the vacuum chamber is heated to a coating temperature of less than 600° C. During sputtering with sputter gas ions, first target particles are liberated from the first target and second target particles are liberated from the second target and are deposited as coating particles on the base body. A first sputter rate is specified for the first target and a second sputter rate is specified for the second target such that, during the sputtering process, the coating is generated as an A15 phase with an intended stoichiometric ratio of the first target particles to the second target particles. A functional element has a base body and a coating of Nb 3 Sn applied directly on the surface of the base body.

The present invention relates to a method and a device for producing ceramics, the method comprising: radiating light onto a ceramic starting material in order to heat this at least in some regions and, as a result, to produce a ceramic product, wherein the radiation of light is carried out simultaneously on a surface of at least 0.1 mm 2 and/or more than 20% of the surface of the ceramic starting material, and wherein the power density of the radiated light is less than 800 W/cm 2 , the device comprising: —at least one receiving means for receiving a ceramic starting material and—at least one light source for radiating light onto the ceramic starting material that is or can be received in the receiving means, the device preferably being configured to radiate the light onto the ceramic starting material in order to heat this at least in some regions and, as a result, to produce a ceramic product, and wherein the receiving means has an insulation.

A host computer with a FPGA is communicatively coupled to a configuration computer via a communication network. The host computer receives target configuration data from the configuration computer in encrypted form. A scanner module that is associated with the host computer decrypts the target configuration data and scans it for malicious code. The module writes the target configuration data to the fabric area of the FPGA and thereby configures the FPGA accordingly, to enable execution of a target array application. The scanner module is associated with the host computer by being implemented as trusted execution environment, or as an on-array-processor.

An automated contact tracing system for anonymously identifying contacts between users includes at least a tracing server; and more than one mobile device or wearable of a user comprising means for short-range proximity communication and means for carrying out a computer program for generating Encounter-Tokens, when one user spent a pre-defined amount of time in a pre-defined proximity range of another user.

The present invention relates to compounds having a fused, substituted tricyclic scaffold and stereo-isomeric forms, solvates, hydrates and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these substituted tricyclic derivatives together with pharmaceutically acceptable carrier, excipient and/or diluents. Said substituted tricyclic derivatives have been identified as especially potent ligands of FK506 binding proteins (FKBPs), especially human FKBP12, FKBP12.6, FKBP51 and FKBP52 or bacterial homologs like LpMip, CtMip, CpMip, NgMip, KpMip, BpMip, TcMip, EcFKLB, EcFKPA, PaFKLB, PaFKPA, AbFKLB, AbFKPA, and are useful for treatment of diseases such as psychiatric, metabolic, infective, neurological and haematological disorders as well as pain and cancers and as anti-inflammatory drugs. Said substituted tricyclic derivatives may further be used as agents for inducing protein-protein interactions (PPIs) acting as molecular glues.

A photoconducting layered material arrangement for producing or detecting high frequency radiation includes a semiconductor material including an alloy comprised of InGaAs, InGaAsSb, or GaSb, with an admixture of Al, which material is applied to a suitable support substrate in a manner such that the lattices are suitably adjusted, wherewith the semiconductor material comprised of InGaAlAs, InGaAlAsSb, or GaAlSb has a band gap of more than 1 eV, as a consequence of the admixed proportion of Al. The proportion x of Al in the semiconductor material In y Ga 1−y−x Al x As is between x=0.2 and x=0.35, wherewith the proportion y of In may be between 0.5 and 0.55. The support substrate is InP or GaAs.

The present invention relates to a process for the production of a compound of Formula (I), wherein the process comprises the step of reacting a plant extract having prenyltransferase activity with a compound of Formula (II) and geranyl pyrophosphate (GPP) having Formula (III) to produce the compound of Formula (I), wherein the plant extract is not a plant extract obtainable from a plant that naturally produces cannabinoids/phytocannabinoids. Accordingly, the present invention relates to a process for the production of a compound of Formula (I), wherein the process comprises the step of reacting a plant extract having prenyltransferase activity with a compound of Formula (II) and geranyl pyrophosphate (GPP) having Formula (III) to produce the compound of Formula (I), wherein the plant extract is not Cannabis sativa plant extract. Further, the present invention relates to the process for the production of a compound of Formula (IV), wherein the process comprises producing a compound of Formula (I) by the process as described herein and converting the compound of Formula (I) to the compound of Formula (IV) in the presence of the tetrahydrocannabinolic acid synthase (THCAS; EC 1.21.3.7). The present invention also relates to a process for the production of a compound of Formula (V) wherein the process comprises producing a compound of Formula (I) by the process as described herein and converting the compound of Formula (I) to a compound of Formula (V) in the presence of the THCAS (EC 1.21.3.7), cannabidiolic acid synthase (CBDAS; EC 1.21.3.8) and/or cannabichromenic acid synthase (CBCAS; EC 1.3.3.-). Further, the present invention relates to a process for the production of a compound of Formula (VI) wherein the process comprises producing a compound of Formula (I) by the process as described herein and converting the compound of Formula (I) to a compound of Formula (VI) in the presence of the CBDAS (EC 1.21.3.8).

An apparatus for additively manufacturing a heterogeneous structure ( 50 ) using a plastic fiber ( 10 ) and an energy transfer material ( 20 ) is disclosed. Additive manufacturing is performed in a vertical direction (z) perpendicular to a horizontal plane (x-y). The apparatus comprises: a nozzle device ( 110 ) adapted to provide the plastic fiber ( 10 ) for additive manufacturing; a feeding device ( 120 ) adapted to move the energy transfer material ( 20 ) back and forth in a vertical direction (z); and moving device ( 130 ) adapted to independently move (or rotate) the feeding device ( 120 ) and the nozzle device ( 110 ) in the horizontal plane (x-y) to fabricate the heterogeneous structure ( 50 ) in the horizontal plane (x-y).