TECHNISCHE UNIVERSITÄT MÜNCHEN

The present invention pertains to novel modified terpene synthases and their use for a preparation method for pseudopterosin intermediates and/or pseudopterosins. The method is based on the use of a modified terpene synthase comprising at least one modified amino acid residue, which enables a terpene synthase-catalyzed increased production of pseudopterosin intermediates and/or pseudopterosins from Geranylgeranyl pyrophosphate as starting material. The new modified terpene synthases of this invention allow the production of pseudopterosin intermediates, such as Isoelisabethatriene A, Isoelisabethatriene B, Erogorgiaene, or Seco-Pseudopterosin and/or the production of pseudopterosins, such as Pseudopterosin A, in a cost-efficient, economical, and sustainable manner. Also provided are nucleic acids, encoding for the modified terpene synthases of this invention, as well as expression vectors capable of expressing such nucleic acids and host cells comprising the same.

The present invention relates to a three-dimensional polynucleotide-based open shells for encapsulating a virus or viral particle, to a composition comprising a mixture of such three-dimensional polynucleotide-based open shells, to a composition comprising a virus or viral particle encapsulated by such three-dimensional polynucleotide-based open shells, and to a method for encapsulating a virus, a viral particle or a subviral particle by using such a three-dimensional polynucleotide-based open shells.

The present invention relates to variants of TEV protease that have—compared to the wildtype enzyme—increased stability and catalytic activity as well as altered substrate specificity. The invention further relates to compositions comprising these variants as well as uses thereof and methods in which these variants are employed.

Embodiments of the present invention provide a method of activating a vehicle function of a vehicle. The vehicle comprises a plurality of energy paths and a plurality of energy consumers, with each energy path of the plurality of energy paths comprising at least one energy consumer of the plurality of energy consumers. The method comprises receiving a command to activate the vehicle function. The command to activate the vehicle function specifies an identifier of the vehicle function. The method further comprises, in response to the command to activate the vehicle function, determining an identifier of an energy path of the plurality of energy paths associated with the identifier of the vehicle function and selectively activating the energy path to provide electrical energy to at least one energy consumer of the plurality of energy consumers. The energy consumer is configured to perform the vehicle function.

The invention relates to a method for sensing target molecules in an analyte solution, a sensor for sensing target molecules in an analyte solution and a measurement system for sensing target molecules in an analyte solution. The method comprises providing a capture surface, wherein a plurality of capture molecules are arranged on the capture surface, each of the capture molecules being configured to bind to at least one of said target molecules. The method further comprises exposing the capture surface to the analyte solution to allow target molecules to bind to the capture molecules arranged on the capture surface. The capture surface is then exposed to a solution containing detection molecules, wherein each of the detection molecules contains an electrochemically active nanoparticle and is configured to bind to one of said target molecules bound to a capture molecule, thereby allowing said electrochemically active nanoparticles to bind to the capture surface through formation of a bond between the respective detection molecule comprising said nanoparticle and one of said target molecules bound to one of said capture molecules arranged on the capture surface. The method further comprises releasing nanoparticles that are bound to the capture surface and, after releasing said nanoparticles from the capture surface, determining an electrical signal at a detection electrode caused by electrochemical reactions of said nanoparticles released from the capture surface.

The present invention relates to a composition for use in the treatment of pulmonary fibrosis of a subject, wherein the composition comprises an inhibitor of miR-21 and a moiety that delivers said inhibitor of miR-21 to a macrophage. Further, the composition may be administered by a pulmonary administration. In particular aspects, said subject to be treated suffers from pulmonary fibrosis and further has a lung disease or disorder, wherein the lung disease or disorder may be a corona virus disease. Furthermore, the invention relates to a composition, wherein the composition comprises an inhibitor of miR-21 and a moiety that delivers said inhibitor of miR-21 to a lung macrophage.

The invention relates to a dynamic nonlinear system having a plurality of degrees of freedom. The system has at least one potential element, and eigenmodes of the system are produced by means of the potential element. A potential is produced by means of the at least one potential element, and the potential causes an acceleration tangential to the basic trajectories of the system, a basic trajectory being a trajectory of the potential-free system.

Provided is a chelate complex comprising (a) a rare earth metal cation M; (b) a chelate ligand of formula (CL1 A) or (CL1 B) c) at least one anionic nucleophilic ligand LN which is coordinated as a further ligand to the rare earth metal cation; and d) optionally one or more neutral donor ligands LD coordinated as ligands to the rare earth metal cation. Moreover, provided are a process for the preparation of a chelate complex, a process for the preparation of a polymer comprising a polymerization reaction of chiral cyclic ester monomers, and a poly(3-hydroxy butyrate) polymer which can be provided by the process.

An oxygen evolution reaction catalyst includes iridium oxide that exhibits a weight loss of less than 1% by weight upon exposure of the oxygen evolution reaction catalyst to a 3.3 vol % hydrogen stream in argon at a temperature of 80° C. for 12 hours and has a BET specific surface area of more than 15 m 2 /g.

The disclosure relates to a method for identification via channels in a system having a plurality of data processing devices. The method comprises selecting, in a first data processing device, an identifier indicative of a target second data processing device of a plurality of second data processing devices; determining, in the first data processing device, an outer codeword from the identifier using an outer code comprising a first outer code and a second outer code; determining, in the first data processing device, an optical orthogonal codeword from the outer codeword using an optical orthogonal code; determining, in the first data processing device; a randomly selected codeword from the optical orthogonal codeword using an error correction code; and emitting the selected codeword from the first data processing device via a channel. Further, a computer program product and a system for identification via channels are provided.