Company patents

UNIVERSITÄT BERN

UNIVERSITÄT BERN's patent strategy reveals a strong, albeit fluctuating, focus on pharmaceutical innovation, with Therapeutic Activity (35.7% of portfolio) and Pharmaceutical Preparations (33.9%) being core areas. While Peptides & Proteins saw an impressive 700.0% YoY growth in 2024, its subsequent decline in 2025 by 62.5% suggests a dynamic, perhaps exploratory, approach to emerging biotech fields, with a partial recovery so far in 2026 (YoY +33.3%).

Patent Trend by Technology Area

Yearly patent publications since 2023

Product themes

Product-level themes inferred from filings since 2023, with category chips showing where each theme appears. Select a theme to filter the patents below.

56 US filings (since 2023) · 11 categories · 24 themes

Nucleic Acid-Based Therapies

Therapeutic strategies employing nucleic acids (DNA, RNA, oligonucleotides) to modulate gene expression, deliver genetic material, or interfere with disease-causing pathways. Includes gene therapy using viral vectors.

Therapeutic Activity (Pharma)Pharmaceutical Preparations
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13since 2023
-40.0%YoY
Advanced Biomarker Detection Assays

Methods and compositions for identifying, quantifying, or characterizing specific biological molecules (e.g., nucleic acids, proteins, metabolites, antibodies) or microbial species, often for diagnostic, prognostic, or quality control applications.

Material & Chemical Analysis
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8since 2023
-33.3%YoY
Targeted Small Molecule Therapeutics

Design and synthesis of acyclic or carbocyclic organic compounds that selectively modulate specific biological targets or pathways for the treatment of diseases.

Pharmaceutical PreparationsHeterocyclic Compounds (Pharma)
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7since 2023
+100.0%YoY
3D Cell & Organoid Culture

Techniques and apparatus for cultivating cells in three-dimensional structures, including organoids, tissue models, and scaffolds, often involving microfluidics, specialized matrices, or mechanical stimulation to mimic in vivo conditions.

Bioreactors / Cell Culture Apparatus
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7since 2023
+100.0%YoY
Targeted Protein Degradation

Development of small molecules, often bifunctional (e.g., PROTACs) or molecular glues, that induce the ubiquitin-proteasome system or autophagy to selectively degrade specific disease-causing proteins.

Heterocyclic Compounds (Pharma)
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6since 2023
+300.0%YoY
Advanced Cell & Gene Therapies

Development of therapeutic approaches involving the genetic modification of cells (e.g., T cells, stem cells, macrophages) or the use of viral/non-viral vectors to deliver genetic material for disease treatment.

Pharmaceutical PreparationsPeptides & Proteins
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6since 2023
-33.3%YoY
Antibody Engineering & Therapeutics

Design and modification of antibodies or antibody-derived fragments for targeted therapeutic intervention, including bispecific formats, Fc region modifications, and activatable constructs.

Therapeutic Activity (Pharma)Peptides & ProteinsPharmaceutical Preparations
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6since 2023
-66.7%YoY
Automated Bioreactor Control

Systems and methods for automated monitoring and dynamic adjustment of environmental parameters (e.g., pH, temperature, oxygen, nutrients) and fluid handling within bioreactors to optimize cell/tissue growth or product synthesis.

Bioreactors / Cell Culture Apparatus
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3since 2023
new
Molecular Biomarkers for Disease

Identification and measurement of specific nucleic acid sequences (DNA, RNA), their expression levels, or epigenetic modifications (e.g., methylation) as indicators for disease presence, progression, risk, or treatment response.

Genetic & Microbiological Assays
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3since 2023
new
Surgical Imaging & Navigation

Systems and methods that use imaging technologies, computer vision, and augmented reality to provide real-time guidance, localization, and visualization during surgical procedures or for detailed anatomical assessment.

Medical Diagnostics & Surgery
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3since 2023
n/a
Targeted Drug Formulation Delivery

Delivery systems specifically engineered to administer advanced drug formulations (e.g., microparticles, biologics, extended-release systems) to achieve precise targeting, controlled release kinetics, or enhanced therapeutic efficacy within the body.

Pharmaceutical Preparations
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2since 2023
new
Protein & Peptide Engineering

Modification of protein or peptide sequences, structures, or post-translational modifications (e.g., glycosylation, lipidation) to enhance their stability, solubility, delivery, or therapeutic efficacy.

Peptides & Proteins
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2since 2023
+100.0%YoY
Wearable Physiological Sensing

Development of devices and methods for non-invasive or minimally invasive collection and analysis of physiological data, often from wearable sensors, to monitor health, activity, or specific conditions.

Medical Diagnostics & Surgery
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2since 2023
+100.0%YoY
Neuromodulation and Electrical Stimulation

Therapeutic application of electrical signals to nerves or tissues to modulate their activity, often using implantable devices, electrodes, and sophisticated programming for various conditions.

Electrotherapy / Radiation Therapy
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2since 2023
new
Magnetic Resonance Sensing

Methods and apparatus for measuring magnetic fields or utilizing magnetic resonance principles for medical diagnostics, material analysis, or precise localization, including gradient field measurement in MRI.

Electrical Measurement
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2since 2023
+100.0%YoY
Cellular Immunotherapy

Therapeutic approaches involving the use of living cells, often genetically modified or ex vivo activated, to treat diseases, particularly cancer, by modulating immune responses or replacing damaged cells.

Therapeutic Activity (Pharma)
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2since 2023
new
Immunomodulatory Protein Design

Design and engineering of proteins or peptides to directly modulate immune responses, including enhancing antigen presentation, suppressing inflammation, or activating specific immune cell types.

Peptides & Proteins
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2since 2023
new
Specialized Culture Substrates & Scaffolds

Development of novel materials, surface patterns, or structural supports designed to enhance cell adhesion, proliferation, differentiation, or tissue formation, including hydrogels and patterned surfaces.

Bioreactors / Cell Culture Apparatus
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2since 2023
new
Bioprocess Development for Proteins

Methods and systems for the efficient and scalable production, purification, and formulation of proteins and peptides, including fermentation, chromatography, and cell-based expression systems.

Peptides & Proteins
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1since 2023
new
AI for Medical Diagnostics

Utilizing machine learning, particularly deep learning, to analyze medical data such as images, sensor readings, or physiological signals for disease prediction, diagnosis, or treatment assessment.

Medical Diagnostics & Surgery
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1since 2023
new
CRISPR-based Nucleic Acid Detection

Assays leveraging CRISPR-Cas systems (e.g., Cas12, Cas13) for highly specific and sensitive detection of target nucleic acids, often involving collateral cleavage activity or reporter molecules.

Genetic & Microbiological Assays
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1since 2023
new
Microbiome & Susceptibility Profiling

Techniques for identifying microorganisms, assessing their viability, quantifying their presence, profiling their metabolic activity, or determining their susceptibility to antimicrobial agents, often in complex biological or environmental samples.

Genetic & Microbiological Assays
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1since 2023
new
Recombinant Protein & Peptide Therapeutics

Development and application of therapeutic proteins or peptides produced through recombinant DNA technology, including fusion proteins and modified growth factors.

Therapeutic Activity (Pharma)
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1since 2023
n/a
Therapeutic Electromagnetic Fields

Use of alternating electric or magnetic fields at specific frequencies and intensities to achieve therapeutic effects, such as inhibiting cell proliferation (e.g., cancer) or modulating cytokine production.

Electrotherapy / Radiation Therapy
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1since 2023
n/a

Patents

Showing 31-40 of 81

Page 4 of 9
US 20240335105 A1APPLICATION
A61B3/08

COMPUTER PROGRAM, METHOD, AND APPARATUS FOR DETERMINING A PLURALITY OF FUNCTIONAL OCULAR PARAMETERS

Filed:2022-07-13Pub:2024-10-10
Applicant:UNIVERSITÄT BERN

The invention relates to a computer program that when executed on a computer causes a system to execute a method, particularly a computer-implemented method for determining a plurality of functional ocular parameters, with the system comprising an optical system ( 3 ) with a display system ( 4 ) that is configured to independently project a visual stimulus to a left and a right eye of a test person, an eye-tracking system ( 5 ) configured to record a gaze direction ( 100 ) and a pupil size ( 102 ) of the left as well as the right eye, said computer ( 2 ) being configured to control the optical system ( 3 ) and to receive recorded data from the eye-tracking system ( 5 ), wherein an afferent pupillary defect (APD), particularly a relative afferent pupillary defect (RAPD) is determined from a first trial session consisting of a sequence of first kind of stimuli presented to the left and the right eye of the test person eyes with the display system ( 4 ), and wherein a visual field ( 400 ) is determined from a second trial session consisting of a sequence of second kind of stimuli presented to the left and the right eye of the test person with the display system ( 4 ), wherein from the first and/or the second trial session a strabismus is determined as well, by determining one or more strabismus angles.

US 20240315548 A1APPLICATION
A61B3/032

COMPUTER PROGRAM, METHOD, AND APPARATUS FOR DETERMINING A VISUAL ACUITY OF A TEST PERSON

Filed:2022-07-13Pub:2024-09-26
Applicant:MACHINEMD AG

The invention relates to a computer program causing a system with a computer to execute a method, particularly a computer-implemented method for determining at least one functional ocular parameter, namely a visual acuity, wherein the system comprises an optical system with a display system that is configured to independently project a visual stimulus to a left and a right eye of a test person, wherein the visual stimulus comprises a plurality of patches arranged on a background, an eye-tracking system configured to record a gaze direction of the left as well as the right eye, a computer configured to control the optical system and to receive recorded data from the eye-tracking system, the method comprising at least the steps of: executing a trial session for determining the visual acuity, wherein the trial session comprises a plurality of the visual stimuli that are presented, with the optical system to the left and/or the right eye of the test person; recording data during the trial session comprising information on the gaze direction; and determining from the recorded data of the trial session at least the visual acuity by analyzing a movement, particularly a correlation of a movement of the left and the right eye of the test person in response to the presented visual stimuli of the trial session, wherein the patches are characterized in that the patches are iso-luminant with respect to the background, that the patches exhibit a luminance distribution that periodically varies with a spatial frequency, and wherein each patch is a bounded set covering only a fraction of the background.

US 20240248954 A1APPLICATION
G06F18/15

ASYNCHRONOUS INTERCORRELATED TIME SERIES DATASETS ALIGNMENT METHOD

Filed:2022-02-08Pub:2024-07-25
Applicant:DOMOHEALTH SA

A computer-implemented method for aligning intercorrelated asynchronous time series datasets includes the steps of: (a) retrieving a first time series dataset (x) and a second time series dataset (y), the first and second time series dataset being intercorrelated, (b) segmenting each of the first and second time series dataset (x, y) into a plurality of consecutive smaller segments (x i , y i ), all segments of the first and second time series dataset (x, y) having the same length, (c) determining pairs of corresponding segments by associating successive segments of the first time series dataset (x) with corresponding segments of the second time series dataset (y), (d) optimizing, for each pair of corresponding segments, a correlation function to obtain an approximation of a first times series transformation function (f 1 ) and of a second time series transformation function (f 2 ), (e) using the first and second time series transformation functions (f 1 ,f 2 ) to determine a vector of segment shifts (s) whose components contain approximations of the shifts between the first and the second segment in a pair of corresponding segments (x i , y i ), (f) applying a multi-model fitting algorithm to the segment shift vector (s), said multi-model algorithm outputting a shift function (f opt ) for aligning segments of each pair of corresponding segments (x i , y i ), and (g) aligning the first time series dataset (x) with the second series dataset by applying said shift function (f opt ) to all pairs of corresponding segments (x i , y i ), wherein the first time series transformation function (f 1 ) is parametrized by weights (w 1 ) of a first neural network (N 1 ) and outputs a first highly correlated time series dataset, and wherein the second time series transformation function (f 2 ) is parametrized by weights (w 2 ) of a second neural network (N 2 ) and outputs a second highly correlated time series dataset.

US 20240225497 A1APPLICATION
A61B5/1455

MEDICAL DEVICE COMPRISING A WEARABLE TEXTILE SENSOR TO PROTECT AGAINST PRESSURE INJURIES

Filed:2022-05-23Pub:2024-07-11
Applicant:UNIVERSITÄT BERN

The present invention relates to a medical device ( 1 ) for determining an oxygen saturation in a tissue of a subject, comprising: a sensor ( 2 ) comprising a flexible textile ( 10 ) comprising a plurality of first optical fibers ( 11 ) and a plurality of second optical fibers ( 12 ), wherein the first optical and second optical fibers ( 11, 12 ) each comprise a first end ( 11 a , 12 a ) and a second end ( 11 b , 12 b ), wherein the sensor ( 2 ) further comprises a first light generating unit ( 3 ) configured to generate and couple light of a first wavelength into the first ends ( 11 a ) of the first optical fibers ( 11 ) and to generate and couple light of a second wavelength into the second ends ( 12 a ) of the first optical fibers ( 11 ), the first wavelength being different from the second wavelength, wherein the respective first optical fiber ( 11 ) is configured to emit light via a light emitting section ( 21 ) of the respective first optical fiber ( 11 ) to irradiate tissue of the subject, the light emitting section ( 21 ) being arranged between the first end ( 11 a ) and the second end ( 11 b ) of the respective first optical fiber ( 11 ), and wherein the respective second optical fiber ( 12 ) comprises a light receiving section ( 22 ) configured to receive light coming from the tissue, the light receiving section ( 22 ) being arranged between the first end ( 12 a ) and the second end ( 12 b ) of the respective second optical fiber ( 12 ), wherein the sensor ( 2 ) further comprises a first light detector unit ( 4 ) operatively connected to the second optical fibers ( 12 ) and configured to detect light received by the light receiving section ( 22 ) of the respective second optical fiber ( 12 ), and an analyzing unit ( 5 ) configured to determine an oxygen saturation value of the tissue using intensities of light detected by the first light detector unit ( 4 ).