Company patents

UNIVERSITÄT BERN

UNIVERSITÄT BERN's patent strategy reveals a strong, albeit fluctuating, focus on pharmaceutical innovation, with Therapeutic Activity (35.7% of portfolio) and Pharmaceutical Preparations (33.9%) being core areas. While Peptides & Proteins saw an impressive 700.0% YoY growth in 2024, its subsequent decline in 2025 by 62.5% suggests a dynamic, perhaps exploratory, approach to emerging biotech fields, with a partial recovery so far in 2026 (YoY +33.3%).

Patent Trend by Technology Area

Yearly patent publications since 2023

Product themes

Product-level themes inferred from filings since 2023, with category chips showing where each theme appears. Select a theme to filter the patents below.

56 US filings (since 2023) · 11 categories · 24 themes

Nucleic Acid-Based Therapies

Therapeutic strategies employing nucleic acids (DNA, RNA, oligonucleotides) to modulate gene expression, deliver genetic material, or interfere with disease-causing pathways. Includes gene therapy using viral vectors.

Therapeutic Activity (Pharma)Pharmaceutical Preparations
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13since 2023
-40.0%YoY
Advanced Biomarker Detection Assays

Methods and compositions for identifying, quantifying, or characterizing specific biological molecules (e.g., nucleic acids, proteins, metabolites, antibodies) or microbial species, often for diagnostic, prognostic, or quality control applications.

Material & Chemical Analysis
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8since 2023
-33.3%YoY
Targeted Small Molecule Therapeutics

Design and synthesis of acyclic or carbocyclic organic compounds that selectively modulate specific biological targets or pathways for the treatment of diseases.

Pharmaceutical PreparationsHeterocyclic Compounds (Pharma)
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7since 2023
+100.0%YoY
3D Cell & Organoid Culture

Techniques and apparatus for cultivating cells in three-dimensional structures, including organoids, tissue models, and scaffolds, often involving microfluidics, specialized matrices, or mechanical stimulation to mimic in vivo conditions.

Bioreactors / Cell Culture Apparatus
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7since 2023
+100.0%YoY
Targeted Protein Degradation

Development of small molecules, often bifunctional (e.g., PROTACs) or molecular glues, that induce the ubiquitin-proteasome system or autophagy to selectively degrade specific disease-causing proteins.

Heterocyclic Compounds (Pharma)
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6since 2023
+300.0%YoY
Advanced Cell & Gene Therapies

Development of therapeutic approaches involving the genetic modification of cells (e.g., T cells, stem cells, macrophages) or the use of viral/non-viral vectors to deliver genetic material for disease treatment.

Pharmaceutical PreparationsPeptides & Proteins
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6since 2023
-33.3%YoY
Antibody Engineering & Therapeutics

Design and modification of antibodies or antibody-derived fragments for targeted therapeutic intervention, including bispecific formats, Fc region modifications, and activatable constructs.

Therapeutic Activity (Pharma)Peptides & ProteinsPharmaceutical Preparations
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6since 2023
-66.7%YoY
Automated Bioreactor Control

Systems and methods for automated monitoring and dynamic adjustment of environmental parameters (e.g., pH, temperature, oxygen, nutrients) and fluid handling within bioreactors to optimize cell/tissue growth or product synthesis.

Bioreactors / Cell Culture Apparatus
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3since 2023
new
Molecular Biomarkers for Disease

Identification and measurement of specific nucleic acid sequences (DNA, RNA), their expression levels, or epigenetic modifications (e.g., methylation) as indicators for disease presence, progression, risk, or treatment response.

Genetic & Microbiological Assays
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3since 2023
new
Surgical Imaging & Navigation

Systems and methods that use imaging technologies, computer vision, and augmented reality to provide real-time guidance, localization, and visualization during surgical procedures or for detailed anatomical assessment.

Medical Diagnostics & Surgery
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3since 2023
n/a
Targeted Drug Formulation Delivery

Delivery systems specifically engineered to administer advanced drug formulations (e.g., microparticles, biologics, extended-release systems) to achieve precise targeting, controlled release kinetics, or enhanced therapeutic efficacy within the body.

Pharmaceutical Preparations
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2since 2023
new
Protein & Peptide Engineering

Modification of protein or peptide sequences, structures, or post-translational modifications (e.g., glycosylation, lipidation) to enhance their stability, solubility, delivery, or therapeutic efficacy.

Peptides & Proteins
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2since 2023
+100.0%YoY
Wearable Physiological Sensing

Development of devices and methods for non-invasive or minimally invasive collection and analysis of physiological data, often from wearable sensors, to monitor health, activity, or specific conditions.

Medical Diagnostics & Surgery
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2since 2023
+100.0%YoY
Neuromodulation and Electrical Stimulation

Therapeutic application of electrical signals to nerves or tissues to modulate their activity, often using implantable devices, electrodes, and sophisticated programming for various conditions.

Electrotherapy / Radiation Therapy
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2since 2023
new
Magnetic Resonance Sensing

Methods and apparatus for measuring magnetic fields or utilizing magnetic resonance principles for medical diagnostics, material analysis, or precise localization, including gradient field measurement in MRI.

Electrical Measurement
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2since 2023
+100.0%YoY
Cellular Immunotherapy

Therapeutic approaches involving the use of living cells, often genetically modified or ex vivo activated, to treat diseases, particularly cancer, by modulating immune responses or replacing damaged cells.

Therapeutic Activity (Pharma)
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2since 2023
new
Immunomodulatory Protein Design

Design and engineering of proteins or peptides to directly modulate immune responses, including enhancing antigen presentation, suppressing inflammation, or activating specific immune cell types.

Peptides & Proteins
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2since 2023
new
Specialized Culture Substrates & Scaffolds

Development of novel materials, surface patterns, or structural supports designed to enhance cell adhesion, proliferation, differentiation, or tissue formation, including hydrogels and patterned surfaces.

Bioreactors / Cell Culture Apparatus
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2since 2023
new
Bioprocess Development for Proteins

Methods and systems for the efficient and scalable production, purification, and formulation of proteins and peptides, including fermentation, chromatography, and cell-based expression systems.

Peptides & Proteins
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1since 2023
new
AI for Medical Diagnostics

Utilizing machine learning, particularly deep learning, to analyze medical data such as images, sensor readings, or physiological signals for disease prediction, diagnosis, or treatment assessment.

Medical Diagnostics & Surgery
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1since 2023
new
CRISPR-based Nucleic Acid Detection

Assays leveraging CRISPR-Cas systems (e.g., Cas12, Cas13) for highly specific and sensitive detection of target nucleic acids, often involving collateral cleavage activity or reporter molecules.

Genetic & Microbiological Assays
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1since 2023
new
Microbiome & Susceptibility Profiling

Techniques for identifying microorganisms, assessing their viability, quantifying their presence, profiling their metabolic activity, or determining their susceptibility to antimicrobial agents, often in complex biological or environmental samples.

Genetic & Microbiological Assays
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1since 2023
new
Recombinant Protein & Peptide Therapeutics

Development and application of therapeutic proteins or peptides produced through recombinant DNA technology, including fusion proteins and modified growth factors.

Therapeutic Activity (Pharma)
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1since 2023
n/a
Therapeutic Electromagnetic Fields

Use of alternating electric or magnetic fields at specific frequencies and intensities to achieve therapeutic effects, such as inhibiting cell proliferation (e.g., cancer) or modulating cytokine production.

Electrotherapy / Radiation Therapy
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1since 2023
n/a

Patents

Showing 41-50 of 81

Page 5 of 9
US 20230340608 A1APPLICATION
C12Q1/6886

PROGNOSTIC BIOMARKERS FOR CANCER

Filed:2021-07-16Pub:2023-10-26
Applicant:EUROPEAN MOLECULAR BIOLOGY LABORATORY

The present invention pertains to a new method for the prognosis, diagnosis, stratification and/or monitoring of a therapy of a disorder in a subject. The method is based on the determination of the level of at least one first biomarker indicative and/or selective for the status and/or activity of the pathway regulating N6-methyladenosine (m6A) mRNA modification, and the determination of the level, mutation status, and/or activity of at least one second biomarker indicative and/or selective for the status and/or activity of the pathway regulating 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U)-tRNA modification as combined biomarkers. The new biomarkers of the invention allow diagnosing and even stratifying of a disorder in a patient, estimating a patient's prognosis, and monitoring therapy success of patients, in particular of cancer patients, such as breast cancer patients. Further provided are kits for the prognosis, diagnosis, and/or monitoring of a disease, condition or disorder in a subject. The invention also pertains to a compound for use in the treatment of a disease, condition or disorder, wherein the compound specifically reduces or enhances the level, mutation status, and/or activity of a gene, mRNA or protein regulating m6A mRNA modification in a cell, and/or a gene, mRNA or protein regulating mcm5s2U-tRNA modification in a cell.

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