Patent Theme
CRISPR-based Nucleic Acid Detection
Assays leveraging CRISPR-Cas systems (e.g., Cas12, Cas13) for highly specific and sensitive detection of target nucleic acids, often involving collateral cleavage activity or reporter molecules.
6,155 US filings from 1,937 companies since 2023 · 2023: 1,602 · 2024: 1,957 · 2025: 1,848 · 2026 YTD: 748
Genetic & Microbiological Assays
Top companies
Ranked by filings in this theme since 2023. 2026 is partial.
| # | Company | Since 2023 | 2023 | 2024 | 2025 | 2026 YTD | YoY |
|---|
| 1 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 224 | 67 | 61 | 68 | 28 | +11.5% |
| 2 | The Broad Institute, Inc. | 200 | 45 | 50 | 75 | 30 | +50.0% |
| 3 | President and Fellows of Harvard College | 183 | 53 | 53 | 51 | 26 | -3.8% |
| 4 | The Regents of the University of California | 183 | 56 | 49 | 61 | 17 | +24.5% |
| 5 | Illumina, Inc. | 131 | 19 | 42 | 48 | 22 | +14.3% |
| 6 | 10x Genomics, Inc. | 118 | 28 | 31 | 36 | 23 | +16.1% |
| 7 | The Board of Trustees of the Leland Stanford Junior University | 77 | 29 | 22 | 19 | 7 | -13.6% |
| 8 | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY | 65 | 16 | 19 | 16 | 14 | -15.8% |
| 9 | Arbor Biotechnologies, Inc. | 61 | 25 | 24 | 8 | 4 | -66.7% |
| 10 | The General Hospital Corporation | 60 | 17 | 20 | 14 | 9 | -30.0% |
| 11 | Oxford Nanopore Technologies PLC | 56 | 11 | 17 | 22 | 6 | +29.4% |
| 12 | Roche Sequencing Solutions, Inc. | 55 | 17 | 17 | 17 | 4 | 0.0% |
| 13 | LIFE TECHNOLOGIES CORPORATION | 51 | 18 | 16 | 13 | 4 | -18.8% |
| 14 | Integrated DNA Technologies, Inc. | 48 | 7 | 15 | 17 | 9 | +13.3% |
| 15 | Alnylam Pharmaceuticals, Inc. | 47 | 7 | 15 | 20 | 5 | +33.3% |
| 16 | GEN-PROBE INCORPORATED | 46 | 11 | 16 | 15 | 4 | -6.2% |
| 17 | Mammoth Biosciences, Inc. | 46 | 10 | 25 | 9 | 2 | -64.0% |
| 18 | The Trustees of Columbia University in the City of New York | 44 | 10 | 14 | 12 | 8 | -14.3% |
| 19 | EDITAS MEDICINE, INC. | 43 | 15 | 14 | 11 | 3 | -21.4% |
| 20 | Metagenomi, Inc. | 40 | 7 | 18 | 12 | 3 | -33.3% |
| 21 | UNIVERSITY OF MASSACHUSETTS | 40 | 10 | 14 | 10 | 6 | -28.6% |
| 22 | VedaBio, Inc. | 40 | 1 | 30 | 7 | 2 | -76.7% |
| 23 | Duke University | 38 | 8 | 11 | 13 | 6 | +18.2% |
| 24 | California Institute of Technology | 36 | 12 | 11 | 11 | 2 | 0.0% |
| 25 | New England Biolabs, Inc. | 36 | 10 | 11 | 6 | 9 | -45.5% |